抑癌蛋白M (英语:Oncostatin M ,缩写OSM ,也译作制癌蛋白M 、抑瘤素M )是由人类基因 OSM 编码 的蛋白质[ 5] ,由209个氨基酸 残基组成。OSM是一种多效的 细胞因子 ,属于IL-6 家族[ 6] ,和白血病抑制因子 (LIF)在结构和功能上类似[ 6] ,在肝脏 发育、造血作用 、炎症 反应以及中枢神经系统 发育和骨形成中有重要作用[ 7] 。
参考文献
^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000099985 - Ensembl , May 2017
^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000058755 - Ensembl , May 2017
^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rose TM, Bruce AG. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6 . Proc. Natl. Acad. Sci. U.S.A. October 1991, 88 (19): 8641–5. PMC 52565 . PMID 1717982 . doi:10.1073/pnas.88.19.8641 .
^ 6.0 6.1 Tanaka M, Miyajima A. Oncostatin M, a multifunctional cytokine. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 2003, 149 : 39–52. ISBN 978-3-540-20213-4 . PMID 12811586 . doi:10.1007/s10254-003-0013-1 .
^ Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice . J Clin Invest. 2010, 120 (2): 582–92 [2019-12-09 ] . PMC 2810087 . PMID 20051625 . doi:10.1172/JCI40568 . (原始内容存档 于2020-05-29). 简明摘要 – ScienceDaily .
延伸阅读
Schieven GL, Kallestad JC, Brown TJ, Ledbetter JA, Linsley PS. Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase. J. Immunol. September 1992, 149 (5): 1676–82. PMID 1324279 .
Hermanns HM, Radtke S, Schaper F, Heinrich PC, Behrmann I. Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to the oncostatin M receptor. J. Biol. Chem. December 2000, 275 (52): 40742–8. PMID 11016927 . doi:10.1074/jbc.M005408200 .
外部链接
趋化因子受体 集落刺激因子 (CSF)
细胞因子受体
IFNAR (α/β, I)
激动剂: Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 )
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (IFNB1 , IFNB3 )
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
IFNGR (γ, II) IFNLR (λ, III)
白介素受体 TGFβ型受体 (TGFβ)TNF受体超家族 (TNFRSF)其它