白桦脂酸
(重定向自桦木酸)
白桦脂酸 | |
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IUPAC名 (3β)-3-Hydroxy-lup-20(29)-en-28-oic acid | |
系统名 (1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-17-hydroxy-1,2,14,18,18-hexamethyl-8-(1-methylethenyl)pentacyclo[11.8.0.02,10.05,9.014,19]henicosane-5-carboxylic acid (1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-1,2,14,18,18-五甲基-8-(1-甲基乙烯基)-17-羟基五环[11.8.0.02,10.05,9.014,19]二十一烷-5-甲酸 | |
别名 | 白桦酯酸 桦木酸 表白桦脂酸 |
识别 | |
CAS号 | 472-15-1 ![]() |
PubChem | 64971 |
ChemSpider | 58496 |
SMILES |
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InChI |
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InChIKey | QGJZLNKBHJESQX-FZFNOLFKBI |
EINECS | 207-448-8 |
ChEBI | 3087 |
IUPHAR配体 | 3945 |
性质 | |
化学式 | C30H48O3 |
摩尔质量 | 456.7 g·mol−1 |
熔点 | 316-318 °C(589-591 K) |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
白桦脂酸(英語:Betulinic acid,也称作白桦酯酸、桦木酸、表白桦脂酸)是一种天然的羽扇豆烷型五环三萜化合物,具有抗逆转录病毒活性,抗疟疾活性和抗炎活性,最近又有报道称能通过抑制拓扑异构酶而具有抗癌活性[1],最早发现于桦木属的一些物种,如毛桦(Betula pubescens)的树皮中[2]因而得名。
另见
参考文献
- ^ Chowdhury AR, Mandal S, Mittra B, Sharma S, Mukhopadhyay S, Majumder HK. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Medical Science Monitor. July 2002, 8 (7): BR254–65. PMID 12118187.
- ^ Tan Y, Yu R, Pezzuto JM. Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clinical Cancer Research. July 2003, 9 (7): 2866–75 [2019-11-23]. PMID 12855667. (原始内容存档于2013-02-23).