Overview of the miRNAs biogenesis. In the canonical pathway in the nucleus, pri-miRNAs are cleaved into pre-miRNAs by Drosha. Pre-miRNAs are exported to the cytoplasm by exportin 5. In the cytoplasm, pre-miRNAs are cleaved into small dsRNAs by Dicer. Then, RISC mediates the recognition of the mRNA to be targeted. In the non-canonical pathway (Mirtron), Drosha cleavage is substituted with splicing. pri-miRNAs (pre-mRNAs) are processed to pre-miRNAs by the spliceosome machinery and debranching enzyme to generate double-stranded loop structures like the regular miRNAs. Subsequently, the RNA product of splicing adopts a pre-miRNA like form, and transferred to the cytoplasm by exportin 5 to continue with the canonical pathway. For more details please refer to the text.
摘要
描述MiRNA-biogenesis.jpg
English: Overview of microRNA processing in animals, from transcription to the formation of the effector complex. There are two pathways, one for microRNAs from independent genes and one for intronic microRNAs.
本圖片是以PNG、GIF或JPEG格式上傳。然而,其中包含的資料或訊息,應該重新建立成可縮放向量圖形(SVG)檔案,以更有效率或更準確的方式儲存。如有可能,請上傳本圖片的SVG格式版本。在上傳之後,請修改維基各姊妹計畫中所有使用舊版圖片的條目(列在圖像連結章節中),替換為新版圖片,並在舊圖片的描述頁中加入{{Vector version available|新圖片名稱.svg}}模板,同時移除本模板。
{{BotMoveToCommons|he.wikipedia|year={{subst:CURRENTYEAR}}|month={{subst:CURRENTMONTHNAME}}|day={{subst:CURRENTDAY}}}} {{Information |Description={{he|תהליכים בסינתזה של he:MicroRNA}} |Source=Transferred from [http://he.wikipedia.o