α-烯醇化酶

Α-烯醇化酶
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2PSN、3B97
識別號
别名	ENO1；, ENO1L1, MPB1, NNE, PPH, HEL-S-17, enolase 1
外部ID	OMIM：172430 MGI：3648653 HomoloGene：134343 GeneCards：ENO1
基因位置（人类）
染色体	1號染色體
终止	8,879,190 bp
基因位置（小鼠）
染色体	小鼠18号染色体
终止	48,181,479 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• DNA结合; • 金屬離子結合; • 血浆蛋白结合; • lyase activity; • GTPase binding; • magnesium ion binding; • RNA binding; • cadherin binding; • DNA结合转录阻遏物活性，RNA聚合酶II特异性; • phosphopyruvate hydratase activity; • protein homodimerization activity; • RNA polymerase II transcription regulatory region sequence-specific DNA binding;
細胞組分	• 細胞質; • M band; • 膜; • 外排體; • 细胞核; • 細胞外空間; • phosphopyruvate hydratase complex; • 细胞质基质; • 细胞膜; • cell surface; • cell cortex region;
生物學過程	• 糖异生; • regulation of transcription, DNA-templated; • 糖酵解; • response to virus; • transcription, DNA-templated; • negative regulation of cell growth; • negative regulation of transcription, DNA-templated; • negative regulation of transcription by RNA polymerase II; • positive regulation of plasminogen activation; • positive regulation of muscle contraction; • canonical glycolysis; • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; • positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	2023
	433182
	ENSG00000074800
	ENSMUSG00000059040
	P06733
	P17182
	NM_001201483; NM_001428; NM_001353346
	NM_001025388
	NP_001188412; NP_001419; NP_001340275
	NP_001366056; NP_001366057; NP_075608; NP_001020559
	維基數據
檢視/編輯人類	檢視/編輯小鼠

α-烯醇化酶（英語：alpha-enolase），也称为烯醇化酶1（enolase 1，ENO1）是人类基因组中编码的三种烯醇化酶（也称做“磷酸烯醇式丙酮酸水合酶”， phosphopyruvate hydratase）之一，以相同亚基形成的蛋白二聚体执行功能，存在選擇性剪接^[5]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000074800 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000059040 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ENO1 enolase 1 (alpha). NCBI Entrez Gene database. [2023-04-18]. （原始内容存档于2023-05-03）.

外部链接

Alpha-Enolase Linked to Severe Asthma - medscape news report, 25 aug 2006.
Human ENO1 genome location and ENO1 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000074800 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000059040 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] ENO1 enolase 1 (alpha). NCBI Entrez Gene database. [2023-04-18]. （原始内容存档于2023-05-03）.

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