免疫相关GTP酶家族M蛋白
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免疫相关GTP酶家族M蛋白(英語:Immunity-related GTPase family M protein,IRGM),亦称为干扰素诱导蛋白1(英語:interferon-inducible protein 1,IFI1),是人体IRGM基因表达的一种酶[6]。
IRGM是干扰素诱导GTP酶家族中的分子量为47kDa的免疫相关鸟苷三磷酸酶(IRGs)成员之一。该基因编码的蛋白可能通过调控对胞内病原体的自噬形成而在先天免疫反应中发挥重要作用。
临床意义
影响该基因表达的多态性位点与克隆氏症和结核病的易感性有关[7]。
参考文献
- ^ 與免疫相关GTP酶家族M蛋白相關的疾病;在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000237693 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000069874 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Entrez Gene: immunity-related GTPase family. (原始内容存档于2009-08-09).
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深入阅读
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免疫相关GTP酶家族M蛋白引用了美国国家医学图书馆提供的資料,这些資料属于公共领域。
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