周期蛋白D1

周期蛋白D1
	Rendering based on PDB 2W96.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2W96, 2W99, 2W9F, 2W9Z
标识
代号	CCND1; BCL1; D11S287E; PRAD1; U21B31
扩展标识	遗传学：168461 鼠基因：88313 同源基因：1334 ChEMBL: 3610 GeneCards: CCND1 Gene
基因本体论描述
分子功能	· protein kinase activity; · protein binding; · cyclin-dependent protein serine/threonine kinase regulator activity; · enzyme binding; · protein kinase binding; · protein complex binding;
细胞成分	· cyclin-dependent protein kinase holoenzyme complex; · intracellular; · nucleus; · nucleoplasm; · cytosol; · tight junction; · membrane;
生物过程	· G1 phase of mitotic cell cycle; · G1/S transition of mitotic cell cycle; · S phase of mitotic cell cycle; · mitotic cell cycle; · re-entry into mitotic cell cycle; · liver development; · positive regulation of protein phosphorylation; · response to DNA damage stimulus; · lactation; · response to iron ion; · response to X-ray; · response to organic nitrogen; · negative regulation of Wnt receptor signaling pathway; · negative regulation of epithelial cell differentiation; · endoplasmic reticulum unfolded protein response; · organ regeneration; · mitotic G1 DNA damage checkpoint; · response to magnesium ion; · response to vitamin E; · Leydig cell differentiation; · mammary gland epithelial cell proliferation; · positive regulation of mammary gland epithelial cell proliferation; · response to drug; · response to estrogen stimulus; · fat cell differentiation; · response to ethanol; · positive regulation of cyclin-dependent protein kinase activity; · cell division; · response to corticosterone stimulus; · response to calcium ion; · canonical Wnt receptor signaling pathway; · mammary gland alveolus development; · response to UV-A; · regulation of G1/S transition of mitotic cell cycle;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
	查; 论; 编;

G1/S-特异性周期蛋白-D1是一个由人类CCND1基因所编码的蛋白质^[1]^[2]。

该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白D1这种亚型的周期蛋白与CDK4或CDK6形成复合物并作为它们的调节亚基，这两种周期蛋白依赖性激酶对于G₁到S期的转变来说是不可或缺的。该蛋白表现出与抑癌基因Rb有着相互作用，且此基因的表达受Rb的正向调控。周期蛋白D1发生突变、扩增及过表达将会改变细胞周期进程，这些现象常发生在多种肿瘤中并可能导致肿瘤发生^[3]。

使用周期蛋白D1进行免疫组化染色可用于诊断套细胞淋巴瘤。

另见

参考文献

^ Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. May 1991, 350 (6318): 512–5. PMID 1826542. doi:10.1038/350512a0.
^ Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. October 1991, 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W.
^ Entrez Gene: CCND1 cyclin D1. （原始内容存档于2009-05-11）.

深入阅读

Akita H. [Prognostic importance of altered expression of cell cycle regulators in lung cancer]. Nippon Rinsho. 2003,. 60 Suppl 5: 267–71. PMID 12101670.
Chung DC. Cyclin D1 in human neuroendocrine: tumorigenesis. Ann. N. Y. Acad. Sci. 2004, 1014: 209–17. PMID 15153436. doi:10.1196/annals.1294.022.
Jain S, Khuri FR, Shin DM. Prevention of head and neck cancer: current status and future prospects. Current Problems in Cancer. 2004, 28 (5): 265–86. PMID 15375804. doi:10.1016/j.currproblcancer.2004.05.003.
Gladden AB, Diehl JA. Location, location, location: the role of cyclin D1 nuclear localization in cancer. J. Cell. Biochem. 2006, 96 (5): 906–13. PMID 16163738. doi:10.1002/jcb.20613.
Walker JL, Assoian RK. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression. Cancer Metastasis Rev. 2006, 24 (3): 383–93. PMID 16258726. doi:10.1007/s10555-005-5130-7.
Gautschi O, Ratschiller D, Gugger M; et al. Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer. 2007, 55 (1): 1–14. PMID 17070615. doi:10.1016/j.lungcan.2006.09.024.
Li Z, Wang C, Prendergast GC, Pestell RG. Cyclin D1 functions in cell migration. Cell Cycle. 2007, 5 (21): 2440–2. PMID 17106256.
Tao Zhang, Breslin MB, Lan MS. Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest. J. Biol. Chem. 2009, 284 (9): 5574–81. PMC 2645817 . PMID 19124461. doi:10.1074/jbc.M808843200.
Inaba T, Matsushime H, Valentine M; et al. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics. 1992, 13 (3): 565–74. PMID 1386335. doi:10.1016/0888-7543(92)90126-D.
Schuuring E, Verhoeven E, Mooi WJ, Michalides RJ. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene. 1992, 7 (2): 355–61. PMID 1532244.
Seto M, Yamamoto K, Iida S; et al. Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation. Oncogene. 1992, 7 (7): 1401–6. PMID 1535701.
Rosenberg CL, Wong E, Petty EM; et al. PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma. Proc. Natl. Acad. Sci. U.S.A. 1991, 88 (21): 9638–42. PMC 52773 . PMID 1682919. doi:10.1073/pnas.88.21.9638.
Xiong Y, Connolly T, Futcher B, Beach D. Human D-type cyclin. Cell. 1991, 65 (4): 691–9. PMID 1827756. doi:10.1016/0092-8674(91)90100-D.
Withers DA, Harvey RC, Faust JB; et al. Characterization of a candidate bcl-1 gene. Mol. Cell. Biol. 1991, 11 (10): 4846–53. PMC 361453 . PMID 1833629.
Tsujimoto Y, Yunis J, Onorato-Showe L; et al. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science. 1984, 224 (4656): 1403–6. PMID 6610211. doi:10.1126/science.6610211.
Hall M, Bates S, Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene. 1995, 11 (8): 1581–8. PMID 7478582.
Tassan JP, Jaquenoud M, Léopold P; et al. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (19): 8871–5. PMC 41069 . PMID 7568034. doi:10.1073/pnas.92.19.8871.
Fornaro M, Dell'Arciprete R, Stella M; et al. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int. J. Cancer. 1995, 62 (5): 610–8. PMID 7665234. doi:10.1002/ijc.2910620520.
Motokura T, Arnold A. PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. Genes Chromosomes Cancer. 1993, 7 (2): 89–95. PMID 7687458. doi:10.1002/gcc.2870070205.

[pmid1826542-1] Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. May 1991, 350 (6318): 512–5. PMID 1826542. doi:10.1038/350512a0.

[pmid1833066-2] Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. October 1991, 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W.

[entrez-3] Entrez Gene: CCND1 cyclin D1. （原始内容存档于2009-05-11）.

[1]

[2]

[3]