室周核
室周核 | |
---|---|
基本信息 | |
系統 | 神经系统 |
标识字符 | |
拉丁文 | nucleus periventricularis |
TA98 | A14.1.08.924 |
TA2 | 5711 |
FMA | FMA:84354 |
《解剖學術語》 [在维基数据上编辑] |
它位于下丘脑的吻侧、中间和尾部区域。喙区有助于生长抑素和甲状腺释放激素的产生。中间部分有助于甲状腺释放激素、生长抑素、瘦素、胃泌素和神经肽 y的产生。在人类和灵长类动物中,它还产生GnRH 。最后,尾部区域有助于交感神经系统调节,被视为愤怒中心。室周核没有有效的血脑屏障。 [1]
在 LH 和 GnRH 释放中的作用
该核已被证明可以通过多种方式影响GnRH(促性腺激素释放激素)的释放。一种方式是神经肽 Y的表达,它对负责 GnRH 分泌的下丘脑通路有影响。 [3]室周核也被证明有许多表达Kisspeptin的神经元,它会产生LH激增,最终导致 GnRH 的释放。 [4]在雌性大鼠中,室周核细胞中雌激素受体β的表达较高,这被认为导致雄性和雌性的 LH 分泌水平不同。 [5]
在 GH 释放中的作用
该区域已被证明有助于生长抑素的产生,研究表明释放生长抑素的神经元受到谷氨酸能神经支配的刺激,从而抑制生长激素的释放。 [6]据认为,男性和女性之间室周核分泌的生长抑素水平存在差异,这被认为是生长激素分泌的性别二态性的原因。 [7]也有人提出,瘦素分泌也在室周核释放 GH 中发挥作用,并且这种激素在 GH 释放途径中与生长抑素和生长激素释放激素(GHRH) 相互作用。 [8]室周核神经元中瘦素受体的存在进一步支持了这一点。 [9] GH 还可能通过增加下丘脑的细胞因子信号传导来抑制 GH 释放途径,从而对室周核提供调节反馈。 [10]
也可以看看
- 前腹室周核
参考
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- ^ Seckl JR. 11β-Hydroxysteroid Dehydrogenase in the Brain: A Novel Regulator of Glucocorticoid Action?. Frontiers in Neuroendocrinology. 1997, 18 (1): 49–99. PMID 9000459. S2CID 46477930. doi:10.1006/frne.1996.0143.
- ^ Chiba, A. Neuropeptide Y-immunoreactive (NPY-ir) structures in the brain of the gar Lepisosteus oculatus (Lepisosteiformes, Osteichthyes) with special regard to their anatomical relations to gonadotropin-releasing hormone (GnRH)-ir structures in the hypothalamus and the terminal nerve. General and Comparative Endocrinology. 2005-07-01, 142 (3): 336–346. PMID 15935160. doi:10.1016/j.ygcen.2005.02.010.
- ^ Rudolph, L. M.; Bentley, G. E.; Calandra, R. S.; Paredes, A. H.; Tesone, M.; Wu, T. J.; Micevych, P. E. Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction. Journal of Neuroendocrinology. 2016-07-01, 28 (7): 10.1111/jne.12405. ISSN 1365-2826. PMC 5146987 . PMID 27329133. doi:10.1111/jne.12405 (英语).
- ^ Orikasa, Chitose; Kondo, Yasuhiko; Hayashi, Shinji; McEwen, Bruce S.; Sakuma, Yasuo. Sexually dimorphic expression of estrogen receptor β in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge. Proceedings of the National Academy of Sciences. 2002-03-05, 99 (5): 3306–3311. Bibcode:2002PNAS...99.3306O. ISSN 0027-8424. PMC 122514 . PMID 11854469. doi:10.1073/pnas.052707299 (英语).
- ^ Kiss, József; Csaba, Zsolt; Csáki, Ágnes; Halász, Béla. Glutamatergic innervation of growth hormone-releasing hormone-containing neurons in the hypothalamic arcuate nucleus and somatostatin-containing neurons in the anterior periventricular nucleus of the rat. Brain Research Bulletin. 2006-10-16, 70 (4–6): 278–288. PMID 17027763. S2CID 3184096. doi:10.1016/j.brainresbull.2006.05.006.
- ^ Murray; Simonian. Correlation of hypothalamic somatostatin mRNA expression and peptide content with secretion: sexual dimorphism and differential regulation by gonadal factors. Neuroendocrinology. 2001, 11 (1): 27–33. PMID 9918226. S2CID 12731896. doi:10.1046/j.1365-2826.1999.00286.x.
- ^ Carro, E.; Señarís, R. M.; Seoane, L. M.; Frohman, L. A.; Arimura, A.; Casanueva, F. F.; Diéguez, C. Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion. Neuroendocrinology. 1999-01-01, 69 (1): 3–10 [2024-01-06]. ISSN 0028-3835. PMID 9892845. S2CID 8220028. doi:10.1159/000054397. (原始内容存档于2018-01-27).
- ^ Håkansson, Marie-Louise; Brown, Hilary; Ghilardi, Nico; Skoda, Radek C.; Meister, Björn. Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus. Journal of Neuroscience. 1998-01-01, 18 (1): 559–572. ISSN 0270-6474. PMC 6793379 . PMID 9412531. doi:10.1523/JNEUROSCI.18-01-00559.1998 (英语).
- ^ Kasagi, Yoko; Tokita, Reiko; Nakata, Tomoko; Imaki, Toshihiro; Minami, Shiro. Human growth hormone induces SOCS3 and CIS mRNA increase in the hypothalamic neurons of hypophysectomized rats. Endocrine Journal. 2004-04-01, 51 (2): 145–154. ISSN 0918-8959. PMID 15118263. doi:10.1507/endocrj.51.145 .