白细胞介素-5

白细胞介素-5
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3VA2、1HUL、3QT2
識別號
别名	IL5；, EDF, IL-5, TRF, interleukin 5
外部ID	OMIM：147850 MGI：96557 HomoloGene：679 GeneCards：IL5
基因位置（人类）
染色体	5號染色體
终止	132,556,838 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	53,615,933 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• interleukin-5 receptor binding; • 血浆蛋白结合; • 生長因子活性; • protein tyrosine kinase activity; • 細胞因子活性;
細胞組分	• 細胞外區域; • 胞內; • 細胞外空間;
生物學過程	• positive regulation of DNA-binding transcription factor activity; • positive regulation of podosome assembly; • MAPK cascade; • positive regulation of transcription, DNA-templated; • 免疫反应; • positive regulation of cell population proliferation; • positive regulation of eosinophil differentiation; • positive regulation of peptidyl-tyrosine phosphorylation; • inflammatory response; • positive regulation of receptor signaling pathway via JAK-STAT; • peptidyl-tyrosine phosphorylation; • positive regulation of B cell proliferation; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	3567
	16191
	ENSG00000113525
	ENSMUSG00000036117
	P05113
	P04401
	NM_000879
	NM_010558
	NP_000870
	NP_034688
	維基數據
檢視/編輯人類	檢視/編輯小鼠

白细胞介素-5（英語：Interleukin-5，缩写IL-5）是一种细胞因子，由人类基因 IL5 编码^[5]，常由II型輔助性T細胞（Th2）和肥大细胞分泌，结合细胞表面的白细胞介素-5受体后发挥作用^[6]。

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000113525 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000036117 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee JS, Campbell HD, Kozak CA, Young IG. The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11. Somatic Cell and Molecular Genetics. March 1989, 15 (2): 143–152. PMID 2784591. S2CID 41719900. doi:10.1007/BF01535075.
^ Milburn MV, Hassell AM, Lambert MH, Jordan SR, Proudfoot AE, Graber P, Wells TN. A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. May 1993, 363 (6425): 172–176. Bibcode:1993Natur.363..172M. PMID 8483502. S2CID 4254991. doi:10.1038/363172a0.