3-甲氧基吗喃

**3-甲氧基吗喃**
法律規範狀態
法律規範	美：uncontrolled;
识别信息
CAS号	1531-25-5
PubChem CID	5484286;
ChemSpider	10207434 ;
UNII	497WV2EY4T;
ECHA InfoCard	100.014.764
化学信息
化学式	C17H23NO
摩尔质量	257.38 g·mol−1
	InChI InChI=1S/C17H23NO/c1-19-13-6-5-12-10-16-14-4-2-3-7-17(14,8-9-18-16)15(12)11-13/h5-6,11,14,16,18H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1 ; Key:ILNSWVUXAPSPEH-USXIJHARSA-N ;

3-甲氧基吗喃（英語：3-Methoxymorphinan）是一种含氮有机化合物，化学式C₁₇H₂₃NO，具有局部麻醉作用^[1]，在体内由酶CYP3A4催化右美沙芬生成,^[2]，再由肝脏中的酶CYP2D6代谢^[3]。

参考文献

^ Hou CH, Tzeng JI, Chen YW, Lin CN, Lin MT, Tu CH, Wang JJ. Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats. European Journal of Pharmacology. August 2006, 544 (1–3): 10–16. PMID 16844109. doi:10.1016/j.ejphar.2006.06.013.
^ Min DI, Ku YM, Vichiendilokkul A, Fleckenstein LL. A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers. Pharmacotherapy. June 1999, 19 (6): 753–759. PMID 10391422. S2CID 32243163. doi:10.1592/phco.19.9.753.31536.
^ Strauch K, Lutz U, Bittner N, Lutz WK. Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. Food and Chemical Toxicology. August 2009, 47 (8): 1928–1935. PMID 19445995. doi:10.1016/j.fct.2009.05.004.