3-甲氧基吗喃
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法律規範狀態 | |
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法律規範 |
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识别信息 | |
CAS号 | 1531-25-5 ![]() |
PubChem CID | |
ChemSpider | |
UNII | |
ECHA InfoCard | 100.014.764 |
化学信息 | |
化学式 | C17H23NO |
摩尔质量 | 257.38 g·mol−1 |
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3-甲氧基吗喃(英語:3-Methoxymorphinan)是一种含氮有机化合物,化学式C17H23NO,具有局部麻醉作用[1],在体内由酶CYP3A4催化右美沙芬生成,[2],再由肝脏中的酶CYP2D6代谢[3]。
参考文献
- ^ Hou CH, Tzeng JI, Chen YW, Lin CN, Lin MT, Tu CH, Wang JJ. Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats. European Journal of Pharmacology. August 2006, 544 (1–3): 10–16. PMID 16844109. doi:10.1016/j.ejphar.2006.06.013.
- ^ Min DI, Ku YM, Vichiendilokkul A, Fleckenstein LL. A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers. Pharmacotherapy. June 1999, 19 (6): 753–759. PMID 10391422. S2CID 32243163. doi:10.1592/phco.19.9.753.31536.
- ^ Strauch K, Lutz U, Bittner N, Lutz WK. Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. Food and Chemical Toxicology. August 2009, 47 (8): 1928–1935. PMID 19445995. doi:10.1016/j.fct.2009.05.004.