ATC代码J01(抗菌药)是解剖学治疗学及化学分类系统的一个药物分组,这是由世界卫生组织药物统计方法整合中心(The WHO Collaborating Centre for Drug Statistics Methodology)所制定的药品及其它医用产品的官方分类系统。分组J01是J抗感染药的一部分。[1]
兽用代码(ATCvet码)可以在人用ATC代码前加Q字母:QJ01等[2]。没有相应人用ATC代码的ATCvet在以下列表中通过前置Q字母表示。
国家ATC分类可能包括列表中没有的其它分类,列表为世界卫生组织(WHO)版本。
J01A 四环素类(Tetracyclines)
J01AA 四环素类(Tetracyclines)
- J01AA01 地美环素(Demeclocycline)
- J01AA02 多西环素(Doxycycline)
- J01AA03 金霉素(Chlortetracycline)
- J01AA04 赖甲环素(Lymecycline)
- J01AA05 美他环素(Metacycline)
- J01AA06 土霉素(Oxytetracycline)
- J01AA07 四环素(Tetracycline)
- J01AA08 米诺环素(Minocycline)
- J01AA09 罗利环素(Rolitetracycline)
- J01AA10 青哌环素(Penimepicycline)
- J01AA11 氯莫环素(Clomocycline)
- J01AA12 替加环素(Tigecycline)
- J01AA20 四环素的复方(Combinations of tetracyclines)
- QJ01AA53 金霉素,复方(Chlortetracycline, combinations)
- J01AA56 土霉素,复方(Oxytetracycline, combinations)
J01B 酰胺醇类(Amphenicols)
J01BA 酰胺醇类(Amphenicols)
- J01BA01 氯霉素(Chloramphenicol)
- J01BA02 甲砜霉素(Thiamphenicol)
- J01BA52 甲砜霉素,复方(Thiamphenicol, combinations)
- QJ01BA90 氟苯尼考(Florfenicol)
- QJ01BA99 酰胺醇,复方(Amphenicols, combinations)
J01C β-内酰胺抗菌药,青霉素类(Beta-lactam antibacterials, penicillins)
J01CA 广谱青霉素类(Penicillins with extended spectrum)
- J01CA01 氨苄西林(Ampicillin)
- J01CA02 匹氨西林(Pivampicillin)
- J01CA03 羧苄西林(Carbenicillin)
- J01CA04 阿莫西林(Amoxicillin)
- J01CA05 卡茚西林(Carindacillin)
- J01CA06 巴氨西林(Bacampicillin)
- J01CA07 依匹西林(Epicillin)
- J01CA08 匹美西林(Pivmecillinam)
- J01CA09 阿洛西林(Azlocillin)
- J01CA10 美洛西林(Mezlocillin)
- J01CA11 美西林(Mecillinam)
- J01CA12 哌拉西林(Piperacillin)
- J01CA13 替卡西林(Ticarcillin)
- J01CA14 美坦西林(Metampicillin)
- J01CA15 酞氨西林(Talampicillin)
- J01CA16 磺苄西林(Sulbenicillin)
- J01CA17 替莫西林(Temocillin)
- J01CA18 海他西林(Hetacillin)
- J01CA19 阿扑西林(Aspoxicillin)
- J01CA20 复方(Combinations)
- J01CA51 氨苄西林,复方(Ampicillin, combinations)
J01CE β-内酰胺酶敏感的青霉素类(Beta-lactamase-sensitive penicillins)
- J01CE01 青霉素G(Benzylpenicillin)
- J01CE02 青霉素V(Phenoxymethylpenicillin)
- J01CE03 异丙西林(Propicillin)
- J01CE04 阿度西林(Azidocillin)
- J01CE05 非奈西林(Pheneticillin)
- J01CE06 培那西林(Penamecillin)
- J01CE07 氯甲西林(Clometocillin)
- J01CE08 苄星青霉素G(Benzathine benzylpenicillin)
- J01CE09 普鲁卡因青霉素(Procaine benzylpenicillin)
- J01CE10 苄星青霉素V(Benzathine phenoxymethylpenicillin)
- J01CE30 复方(Combinations)
- QJ01CE90 Penethamate hydroiodide
J01CF 耐β-内酰胺酶的青霉素类(Beta-lactamase-resistant penicillins)
- J01CF01 双氯西林(Dicloxacillin)
- J01CF02 氯唑西林(Cloxacillin)
- J01CF03 甲氧西林(Methicillin)
- J01CF04 苯唑西林(Oxacillin)
- J01CF05 氟氯西林(Flucloxacillin)
- QJ01CF06 奈夫西林(Nafcillin)
J01CG β-内酰胺酶抑制药(Beta-lactamase inhibitors)
- J01CG01 舒巴坦(Sulbactam)
- J01CG02 三唑巴坦(Tazobactam)
J01CR 青霉素(含β-内酰胺酶抑制剂)类的复方(Combinations of penicillins, including beta-lactamase inhibitors)
- J01CR01 氨苄西林和酶抑制剂(Ampicillin and enzyme inhibitor)
- J01CR02 阿莫西林和酶抑制剂(Amoxicillin and enzyme inhibitor)
- J01CR03 替卡西林和酶抑制剂(Ticarcillin and enzyme inhibitor)
- J01CR04 舒他西林(Sultamicillin)
- J01CR05 哌拉西林和酶抑制药(Piperacillin and enzyme inhibitor)
- J01CR50 青霉素类复方(Combinations of penicillins)
J01D 其它β-内酰胺类抗菌药(Other beta-lactam antibacterials)
J01DB 第一代头孢菌素(First-generation cephalosporins)
- J01DB01 头孢氨苄(头孢力新,先锋霉素IV)(Cefalexin)
- J01DB02 头孢噻啶(头孢娄利定,先锋霉素II)(Cefaloridine)
- J01DB03 头孢噻吩(头孢娄新,先锋霉素I)(Cefalotin)
- J01DB04 头孢唑林(头孢菌素V,先锋霉素V)(Cefazolin)
- J01DB05 头孢羟氨苄(Cefadroxil)
- J01DB06 头孢西酮(Cefazedone)
- J01DB07 头孢曲秦(Cefatrizine)
- J01DB08 头孢匹林(先锋霉素VIII)(Cefapirin)
- J01DB09 头孢拉定(先锋霉素VI,头孢环己烯,环己烯胺头孢菌素)(Cefradine)
- J01DB10 头孢乙腈(氰甲头孢菌素,头孢赛曲)(Cefacetrile)
- J01DB11 头孢沙定(Cefroxadine)
- J01DB12 头孢替唑(头孢去甲唑啉)(Ceftezole)
J01DC 第二代头孢菌素(Second-generation cephalosporins)
- J01DC01 头孢西丁(美福仙,先锋美吩,头霉噻吩,头孢甲氧霉素)(Cefoxitin)
- J01DC02 头孢呋辛(头孢氨呋肟,呋肟头孢菌素)(Cefuroxime)
- J01DC03 头孢孟多(头孢羟唑)(Cefamandole)
- J01DC04 头孢克洛(头孢克罗,头孢氯氨苄)(Cefaclor)
- J01DC05 头孢替坦(头孢双硫唑甲氧)(Cefotetan)
- J01DC06 头孢尼西(头孢羟苄磺唑)(Cefonicide)
- J01DC07 头孢替安(头孢噻乙胺唑,噻乙胺唑头孢菌素)(Cefotiam)
- J01DC08 氯碳头孢(Loracarbef)
- J01DC09 头孢美唑(Cefmetazole)
- J01DC10 头孢丙烯(Cefprozil)
- J01DC11 头孢雷特(Ceforanide)
- J01DC12 头孢米诺(Cefminox)
- J01DC13 头孢拉宗(Cefbuperazone)
- J01DC14 氟氧头孢
J01DD 第三代头孢菌素(Third-generation cephalosporins)
- J01DD01 头孢噻肟(头孢氨噻,头孢氨噻肟,先锋龙)(Cefotaxime)
- J01DD02 头孢他啶(头孢噻甲羧肟)(Ceftazidime)
- J01DD03 头孢磺啶(磺吡苄头孢菌素,头孢磺吡酮)(Cefsulodin)
- J01DD04 头孢曲松(头孢三嗪,头孢嗪克松,头孢氨噻三嗪)(Ceftriaxone)
- J01DD05 头孢甲肟(头孢氨噻肟唑)(Cefmenoxime)
- J01DD06 拉氧头孢(Latamoxef)
- J01DD07 头孢唑肟(去甲噻肟头孢菌素,头孢甲噻肟,安保速灵,安普西林)(Ceftizoxime)
- J01DD08 头孢克肟(Cefixime)
- J01DD09 头孢地秦(Cefodizime)
- J01DD10 头孢他美(Cefetamet)
- J01DD11 头孢匹胺(头孢吡四唑)(Cefpiramide)
- J01DD12 头孢哌酮(Cefoperazone)
- J01DD13 头孢泊肟(Cefpodoxime)
- J01DD14 头孢布烯(头孢布坦, 先力腾, 头孢噻腾)(Ceftibuten)
- J01DD15 头孢地尼(Cefdinir)
- J01DD16 头孢托仑(Cefditoren)
- J01DD17 头孢卡品(Cefcapene)
- J01DD54 头孢曲松,复方(Ceftriaxone, combinations)
- J01DD62 头孢哌酮,复方(Cefoperazone, combinations)
- QJ01DD90 头孢噻呋(Ceftiofur)
- QJ01DD91 头孢维星(Cefovecin)
J01DE 第四代头孢菌素(Fourth-generation cephalosporins)
- J01DE01 头孢吡肟(头孢匹美)(Cefepime)
- J01DE02 头孢匹罗(Cefpirome)
- J01DE03 头孢唑兰(Cefozopran)
- QJ01DE90 Cefquinome
J01DF 单环β-内酰胺类(Monobactams)
- J01DF01 氨曲南(氨噻羧单胺菌素,噻肟单酰胺菌素)(Aztreonam)
- J01DF02 Carumonam
J01DH 碳青霉烯类(Carbapenems)
- J01DH02 美罗培南(Meropenem)
- J01DH03 厄他培南(Ertapenem)
- J01DH04 多尼培南(Doripenem)
- J01DH05 比阿培南(Biapenem)
- J01DH51 亚胺培南和酶抑制药(Imipenem and enzyme inhibitor)
- J01DH55 帕尼培南和倍他米隆(Panipenem and betamipron)
J01DI 其它头孢菌素(Other cephalosporins)
- J01DI01 头孢比洛酯(Ceftobiprole medocaril)
- J01DI02 头孢洛林
J01E 磺胺类和甲氧苄啶(Sulfonamides and trimethoprim)
- J01EA–E只包括人类使用的ATC分类。 Subgroups J01EA–E are only included in the human ATC classification.
J01EA 甲氧苄啶及其衍生物(Trimethoprim and derivatives)
- J01EA01 甲氧苄啶(Trimethoprim)
- J01EA02 溴莫普林(Brodimoprim)
- J01EA03 艾拉普林(Iclaprim)
J01EB 短效磺胺类(Short-acting sulfonamides)
- J01EB01 磺胺二甲异嘧啶(Sulfaisodimidine)
- J01EB02 磺胺甲噻二唑(Sulfamethizole)
- J01EB03 磺胺二甲嘧啶(Sulfadimidine)
- J01EB04 磺胺吡啶(Sulfapyridine)
- J01EB05 磺胺异噁唑(Sulfafurazole)
- J01EB06 磺胺(Sulfanilamide)
- J01EB07 磺胺噻唑(Sulfathiazole)
- J01EB08 磺胺硫脲(Sulfathiourea)
- J01EB20 复方(Combinations)
- J01EC01 磺胺甲噁唑(Sulfamethoxazole)
- J01EC02 磺胺嘧啶(Sulfadiazine)
- J01EC03 磺胺恶唑(Sulfamoxole)
- J01EC20 复方(Combinations)
J01ED 长效磺胺类(Long-acting sulfonamides)
- J01ED01 磺胺地索辛(Sulfadimethoxine)
- J01ED02 磺胺嘧啶(Sulfalene)
- J01ED03 磺胺托嘧啶(Sulfametomidine)
- J01ED04 磺胺对甲氧嘧啶(Sulfametoxydiazine)
- J01ED05 磺胺甲氧哒嗪(Sulfamethoxypyridazine)
- J01ED06 磺胺培林(Sulfaperin)
- J01ED07 磺胺甲基嘧啶(Sulfamerazine)
- J01ED08 磺胺苯吡唑(Sulfaphenazole)
- J01ED09 磺胺马宗(Sulfamazon)
- J01ED20 复方(Combinations)
J01EE 磺胺类和甲氧苄啶(含其衍生物)的复方(Combinations of sulfonamides and trimethoprim, including derivatives)
- J01EE01 磺胺甲噁唑和甲氧苄啶(Sulfamethoxazole and trimethoprim)
- J01EE02 磺胺嘧啶和甲氧苄啶(Sulfadiazine and trimethoprim)
- J01EE03 磺胺美曲和甲氧苄啶(Sulfametrole and trimethoprim)
- J01EE04 磺胺噁唑和甲氧苄啶(Sulfamoxole and trimethoprim)
- J01EE05 磺胺二甲嘧啶和甲氧苄啶(Sulfadimidine and trimethoprim)
- J01EE06 磺胺嘧啶和四氧普林(Sulfadiazine and tetroxoprim)
- J01EE07 磺胺甲嘧啶和甲氧苄啶(Sulfamerazine and trimethoprim)
QJ01EQ 磺胺类(Sulfonamides)
- QJ01EQ01 Sulfapyrazole
- QJ01EQ02 磺胺甲噻二唑(Sulfamethizole)
- QJ01EQ03 磺胺二甲嘧啶(Sulfadimidine)
- QJ01EQ04 磺胺吡啶(Sulfapyridine)
- QJ01EQ05 磺胺异噁唑(Sulfafurazole)
- QJ01EQ06 磺胺(Sulfanilamide)
- QJ01EQ07 磺胺噻唑(Sulfathiazole)
- QJ01EQ08 磺胺苯吡唑(Sulfaphenazole)
- QJ01EQ09 磺胺地索辛(Sulfadimethoxine)
- QJ01EQ10 磺胺嘧啶(Sulfadiazine)
- QJ01EQ11 磺胺甲噁唑(Sulfamethoxazole)
- QJ01EQ12 磺胺氯哒嗪(Sulfachlorpyridazine)
- QJ01EQ13 磺胺多辛(Sulfadoxine)
- QJ01EQ14 磺胺曲沙唑(Sulfatroxazol)
- QJ01EQ15 磺胺甲氧嗪(Sulfamethoxypyridazine)
- QJ01EQ16 Sulfazuinoxaline
- QJ01EQ17 磺胺甲嘧啶Sulfamerazine
- QJ01EQ30 磺胺类的复方(Combinations of sulfonamides)
- QJ01EQ59 磺胺地索辛、复方(Sulfadimethoxine, combinations)
QJ01EW 磺胺类药物和甲氧苄啶的组合,包括衍生物(Combinations of sulfonamides and trimethoprim, including derivatives)
- QJ01EW03 磺胺二甲嘧啶和甲氧苄啶(Sulfadimidine and trimethoprim
- QJ01EW09 磺胺地索辛和甲氧苄啶 (Sulfadimethoxine and trimethoprim)
- QJ01EW10 磺胺嘧啶和甲氧苄啶(Sulfadiazine and trimethoprim)
- QJ01EW11 磺胺甲噁唑和甲氧苄啶(Sulfamethoxazole and trimethoprime)
- QJ01EW12 磺胺氯哒嗪和甲氧苄啶(Sulfachlorpyridazine and trimethoprim)
- QJ01EW13 磺胺多辛和甲氧苄啶(Sulfadoxine and trimethoprim)
- QJ01EW14 磺胺曲沙唑和甲氧苄啶(Sulfatroxazol and trimethoprim)
- QJ01EW15 磺胺甲氧嗪和甲氧苄啶(Sulfamethoxypyridazine and trimethoprim)
- QJ01EW16 磺胺喹恶啉和甲氧苄啶(Sulfaquinoxaline and trimethoprim)
- QJ01EW17 磺胺间甲氧嘧啶和甲氧苄啶(Sulfamonomethoxine and trimethoprim)
- QJ01EW18 磺胺甲嘧啶和甲氧苄啶(Sulfamerazine and trimethoprim)
- QJ01EW30 磺胺类和甲氧苄啶的复方(Combinations of sulfonamides and trimethoprim)
J01FA 大环内酯类(Macrolides)
- J01FA01 红霉素(Erythromycin)
- J01FA02 螺旋霉素(Spiramycin)
- J01FA03 麦迪霉素(Midecamycin)
- J01FA05 竹桃霉素(Oleandomycin)
- J01FA06 罗红霉素(Roxithromycin)
- J01FA07 交沙霉素(Josamycin)
- J01FA08 醋竹桃霉素(Troleandomycin)
- J01FA09 克拉霉素(Clarithromycin)
- J01FA10 阿奇霉素(Azithromycin)
- J01FA11 妙卡霉素(Miocamycin)
- J01FA12 罗他霉素(Rokitamycin)
- J01FA13 地红霉素(Dirithromycin)
- J01FA14 氟红霉素(Flurithromycin)
- J01FA15 特利霉素(Telithromycin)
- QJ01FA90 Tylosin
- QJ01FA91 替米考星
- QJ01FA92 Tylvalosin
- QJ01FA93 Kitasamycin
- QJ01FA94 Tulathromycin
- QJ01FA95 Gamithromycin
- QJ01FA96 Tildipirosin
J01FF 林可酰胺类(Lincosamides)
- J01FF01 克林霉素(Clindamycin)
- J01FF02 林可霉素(Lincomycin)
- QJ01FF52 Lincomycin, combinations
J01FG 链霉杀阳菌素类(Streptogramins)
- J01FG01 普那霉素(Pristinamycin)
- J01FG02 奎奴普汀(达福普汀)(Quinupristin/dalfopristin)
- QJ01FG90 Virginiamycin
J01G 氨基糖苷类抗菌药(Aminoglycoside antibacterials)
J01GA 链霉素类(Streptomycins)
- J01GA01 链霉素(Streptomycin)
- J01GA02 链双霉素(Streptoduocin)
- QJ01GA90 双氢链霉素(Dihydrostreptomycin)
J01GB 其它氨基糖苷类(Other aminoglycosides)
- J01GB01 妥布霉素(Tobramycin)
- J01GB03 庆大霉素(Gentamicin)
- J01GB04 卡那霉素(Kanamycin)
- J01GB05 新霉素(Neomycin)
- J01GB06 阿米卡星(Amikacin)
- J01GB07 奈替米星(Netilmicin)
- J01GB08 西索米星(紫苏霉素,西索霉素,西梭霉素)(Sisomicin)
- J01GB09 地贝卡星(Dibekacin)
- J01GB10 核糖霉素(Ribostamycin)
- J01GB11 异帕米星(Isepamicin)
- J01GB12 阿贝卡星(Arbekacin)
- J01GB13 Bekanamycin
- QJ01GB90 阿泊拉霉素(Apramycin)
- QJ01GB91 新霉素
J01M 喹诺酮类抗菌药(Quinolone antibacterials)
- 兽用代码ATCvet,这个分组被命名为“QJ01M 喹诺酮类和喹啉类抗菌药”。
J01MA 氟喹诺酮类(Fluoroquinolones)
- J01MA01 氧氟沙星(Ofloxacin)
- J01MA02 环丙沙星(Ciprofloxacin)
- J01MA03 培氟沙星(Pefloxacin)
- J01MA04 依诺沙星(氟啶酸,氟哌酸,力醇罗)(Enoxacin)
- J01MA05 替马沙星(Temafloxacin)
- J01MA06 诺氟沙星(Norfloxacin)
- J01MA07 洛美沙星(Lomefloxacin)
- J01MA08 氟罗沙星(Fleroxacin)
- J01MA09 司帕沙星(Sparfloxacin)
- J01MA10 芦氟沙星(Rufloxacin)
- J01MA11 格帕沙星(Grepafloxacin)
- J01MA12 左氧氟沙星(Levofloxacin)
- J01MA13 曲伐沙星(Trovafloxacin)
- J01MA14 莫西沙星(Moxifloxacin)
- J01MA15 吉米沙星(Gemifloxacin)
- J01MA16 加替沙星(Gatifloxacin)
- J01MA17 普卢利沙星(Prulifloxacin)
- J01MA18 帕珠沙星(Pazufloxacin)
- J01MA19 加雷沙星(Garenoxacin)
- J01MA21 Sitafloxacin
- QJ01MA90 Enrofloxacin
- QJ01MA92 Danofloxacin
- QJ01MA93 Marbofloxacin
- QJ01MA94 Difloxacin
- QJ01MA95 Orbifloxacin
- QJ01MA96 Ibafloxacin
- QJ01MA97 Pradofloxacin
J01MB 其它喹诺酮类(Other quinolones)
- J01MB01 罗索沙星(Rosoxacin)
- J01MB02 萘啶酸(Nalidixic acid)
- J01MB03 吡咯米酸(吡咯酸)(Piromidic acid)
- J01MB04 吡哌酸(Pipemidic acid)
- J01MB05 奥索利酸(噁喹酸)(Oxolinic acid)
- J01MB06 西诺沙星(Cinoxacin)
- J01MB07 氟甲喹(Flumequine)
QJ01MQ 喹喔啉(Quinoxalines)
- QJ01MQ01 喹乙醇Olaquindox
J01R 抗菌药复方(Combinations of antibacterials)
J01RA 抗菌药复方(Combinations of antibacterials)
- J01RA01 青霉素类与其它抗菌药的复方(Penicillins, combinations with other antibacterials)
- J01RA02 磺胺类与其它抗菌药(甲氧苄啶除外)的复方(Sulfonamides, combinations with other antibacterials (excluding trimethoprim))
- J01RA03 头孢呋辛与其它抗菌药的复方(Cefuroxime, combinations with other antibacterials)
- J01RA04 螺旋霉素,与其它抗菌药的复方(Spiramycin, combinations with other antibacterials)
- QJ01RA90 Tetracyclines, combinations with other antibacterials
- QJ01RA91 Macrolides, combinations with other antibacterials
- QJ01RA92 Amphenicols, combinations with other antibacterials
- QJ01RA94 Lincosamides, combinations with other antibacterials
- QJ01RA95 Polymyxins, combinations with other antibacterials
- QJ01RA96 Quinolones, combinations with other antibacterials
- QJ01RA97 Aminoglycosides, combinations with other antibacterials
QJ01RV 抗菌药物和其他物质的复方(Combinations of antibacterials and other substances)
- QJ01RV01 抗菌药和皮质类固醇(Antibacterials and corticosteroids)
J01X 其它抗菌药(Other antibacterials)
J01XA 糖肽类抗菌药(Glycopeptide antibacterials)
- J01XA01 万古霉素(Vancomycin)
- J01XA02 替考拉宁(Teicoplanin)
- J01XA03 泰拉万星(Telavancin)
- J01XA04 达巴万星(Dalbavancin)
- J01XA05 奥利万星(Oritavancin)
J01XB 多粘菌素类(Polymyxins)
- J01XB01 多粘菌素(Colistin)
- J01XB02 多粘菌素B(Polymyxin B)
J01XC 甾体类抗菌药(Steroid antibacterials)
- J01XC01 夫西地酸(Fusidic acid)
J01XD 咪唑衍生物(Imidazole derivatives)
- J01XD01 甲硝唑(Metronidazole)
- J01XD02 替硝唑(硝砜咪唑)(Tinidazole)
- J01XD03 奥硝唑(Ornidazole)
J01XE 硝基呋喃衍生物(Nitrofuran derivatives)
- J01XE01 呋喃妥因(Nitrofurantoin)
- J01XE02 硝呋妥因醇(Nifurtoinol)
- QJ01XE90 呋喃唑酮
QJ01XQ 截短侧耳素(Pleuromutilins)
- QJ01XQ01 泰妙菌素(Tiamulin)
- QJ01XQ02 伐奈莫林(Valnemulin)
J01XX 其它抗菌药(Other antibacterials)
- J01XX01 磷霉素(Fosfomycin)
- J01XX02 希波酚(异冰片二甲酚)(Xibornol)
- J01XX03 氯福克酚(Clofoctol)
- J01XX04 大观霉素(Spectinomycin)
- J01XX05 乌洛托品(环六亚甲基四胺)(Methenamine)
- J01XX06 扁桃酸(Mandelic acid)
- J01XX07 硝羟喹啉(Nitroxoline)
- J01XX08 利奈唑胺(Linezolid)
- J01XX09 达托霉素(Daptomycin)
- J01XX10 杆菌肽(Bacitracin)
- QJ01XX55 乌洛托品,复方(Methenamine, combinations)
- QJ01XX93 Furaltadone
- QJ01XX95 Novobiocin
参考资料
- ^ ATC Index. WHO Collaborating Centre for Drug Statistics Methodology.
- ^ ATCvet Index. WHO Collaborating Centre for Drug Statistics Methodology.