CYP46A1

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	Structure of cholesterol-24 hydroxlase (CYP46A1) in Homo sapiens. Based on PyMOL rendering of PDB 2Q9F.
命名
系统命名
缩写
识别码
EC編號	1.14.13.98
数据库
IntEnz	IntEnz浏览
BRENDA（英语：BRENDA）	BRENDA入口
ExPASy（英语：ExPASy）	NiceZyme浏览
KEGG	KEGG入口
MetaCyc（英语：MetaCyc）	代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
搜索
PMC	相关文献
PubMed	相关文献

CYP46A1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4FIA、2Q9F、3MDV、4J14、4ENH、2Q9G、3MDM、3MDT、3MDR
識別號
别名	CYP46A1；, CP46, CYP46, cytochrome P450 family 46 subfamily A member 1
外部ID	OMIM：604087 MGI：1341877 HomoloGene：134501 GeneCards：CYP46A1
基因位置（人类）
染色体	14號染色體
终止	99,727,301 bp
基因位置（小鼠）
染色体	小鼠12号染色体
终止	108,328,493 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• iron ion binding; • 金屬離子結合; • monooxygenase activity; • steroid hydroxylase activity; • heme binding; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • oxidoreductase activity; • cholesterol 24-hydroxylase activity;
細胞組分	• organelle membrane; • integral component of membrane; • endoplasmic reticulum membrane; • 膜; • 細胞內膜結合細胞器; • 内质网; • 树突; • presynapse; • postsynapse; • 细胞连接; • cell projection; • 突触;
生物學過程	• steroid metabolic process; • 脂質代謝; • cholesterol metabolic process; • cholesterol catabolic process; • 神經系統的發育; • sterol metabolic process; • bile acid biosynthetic process; • xenobiotic metabolic process; • progesterone metabolic process; • regulation of long-term synaptic potentiation; • C21-steroid hormone metabolic process;
	Sources:Amigo / QuickGO
直系同源
	10858
	13116
	ENSG00000036530
	ENSMUSG00000021259
	Q9Y6A2
	Q9WVK8
	NM_006668
	NM_010010
	NP_006659
	NP_034140
	維基數據
檢視/編輯人類	檢視/編輯小鼠

细胞色素 P450 46A1（英語：Cytochrome P450 46A1，缩写CYP46A1）也被称为胆固醇24-羟化酶（chilsterol 24-hydroxylase，EC 1.14.13.98），是细胞色素P450超家族的一员，由CYP46A1基因编码，是催化胆固醇生成羟基化生成脑甾醇（24S-羟基胆固醇）的酶^[5]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000036530 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000021259 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Russell DW; Halford RW; Ramirez DMO; Shah R; Kotti T. Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annual Review of Biochemistry. 2009, 78: 1017–1040. PMC 2837268 . PMID 19489738. doi:10.1146/annurev.biochem.78.072407.103859.

外部链接

GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis（页面存档备份，存于互联网档案馆）
醫學主題詞表（MeSH）：Cytochrome+P-450+CYP27A1
Human CYP27A1 genome location and CYP27A1 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000036530 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000021259 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[russell2009-5] Russell DW; Halford RW; Ramirez DMO; Shah R; Kotti T. Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annual Review of Biochemistry. 2009, 78: 1017–1040. PMC 2837268 . PMID 19489738. doi:10.1146/annurev.biochem.78.072407.103859.

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