O-1918
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| 识别信息 | |
|---|---|
| |
| CAS号 | 536697-79-7  |
| PubChem CID | |
| UNII | |
| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C19H26O2 |
| 摩尔质量 | 286.19 |
| 3D模型（JSmol） | |
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O-1918是一种人工合成的有机化合物，分子式C19H26O2，化学结构上与大麻二酚相似，可作为前孤儿受体G蛋白偶联受体GPR18和GPR55的受体拮抗剂。[1][2][3][4][5]
参考文献
- ^ Offertáler L, Mo FM, Bátkai S, et al. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Molecular Pharmacology. March 2003, 63 (3): 699–705. PMID 12606780. doi:10.1124/mol.63.3.699.
- ^ Zakrzeska A, Schlicker E, Baranowska M, et al. A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats. British Journal of Pharmacology. June 2010, 160 (3): 574–84. PMC 2931558
. PMID 20105178. doi:10.1111/j.1476-5381.2009.00579.x.
- ^ Schuelert N, McDougall JJ. The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. Neuroscience Letters. August 2011, 500 (1): 72–6. PMID 21683763. S2CID 3410391. doi:10.1016/j.neulet.2011.06.004.
- ^ Szczesniak AM, Maor Y, Robertson H, et al. Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure. Journal of Ocular Pharmacology and Therapeutics. October 2011, 27 (5): 427–35. PMID 21770780. doi:10.1089/jop.2011.0041.
- ^ Caldwell MD, Hu SS, Viswanathan S, et al. A GPR18-based signalling system regulates IOP in murine eye. British Journal of Pharmacology. June 2013, 169 (4): 834–43. PMC 3687663 . PMID 23461720. doi:10.1111/bph.12136.
