Ro01-6128

维基百科,自由的百科全书
Ro01-6128
识别信息
  • ethyl diphenylacetylcarbamate
PubChem CID
IUPHAR/BPS
ChemSpider
化学信息
化学式C17H17NO3
摩尔质量283.33 g·mol−1
3D模型(JSmol英语JSmol
  • c2ccccc2C(C(=O)NC(=O)OCC)c1ccccc1
  • InChI=1S/C17H17NO3/c1-2-21-17(20)18-16(19)15(13-9-5-3-6-10-13)14-11-7-4-8-12-14/h3-12,15H,2H2,1H3,(H,18,19,20)
  • Key:ILSZPWZFQHSKLW-UHFFFAOYSA-N

Ro01-6128是一种含氮有机化合物,化学式为C17H17NO3,作为代谢型谷氨酸受体GRM1别构调节剂用于科学研究。[1][2][3]

参考文献

  1. ^ Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proceedings of the National Academy of Sciences of the United States of America. November 2001, 98 (23): 13402–7. Bibcode:2001PNAS...9813402K. PMC 60883可免费查阅. PMID 11606768. doi:10.1073/pnas.231358298可免费查阅. 
  2. ^ Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Molecular Pharmacology. August 2006, 70 (2): 616–26. PMID 16645124. S2CID 2719603. doi:10.1124/mol.105.021857. 
  3. ^ Sheffler DJ, Conn PJ. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology. September 2008, 55 (4): 419–27. PMC 2600811可免费查阅. PMID 18625258. doi:10.1016/j.neuropharm.2008.06.047. 

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