氧丙咪嗪
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临床资料 | |
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商品名 | Imiprex, Elepsin |
给药途径 | Oral |
ATC码 | |
法律规范状态 | |
法律规范 |
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药物动力学数据 | |
生物半衰期 | Intravenous: 1.8 hours[1] |
识别信息 | |
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CAS号 | 6829-98-7 |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.027.188 |
化学信息 | |
化学式 | C19H24N2O |
摩尔质量 | 296.41 g·mol−1 |
氧丙咪嗪(英语:Imipraminoxide 或 imipramine N-oxide,商品名:Imiprex、Elepsin),分子式C19H24N2O,是一种用于治疗重性抑郁疾患的三环类抗抑郁药(TCA),1960年代开始在欧洲使用,也是丙咪嗪在体内的代谢产物。[3][4][5][6]
参考文献
- ^ Florencio Zaragoza Dörwald. Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds. John Wiley & Sons. 4 February 2013: 311–. ISBN 978-3-527-64565-7.
- ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. (原始内容存档于2023-08-03) (巴西葡萄牙语).
- ^ Swiss Pharmaceutical Society. Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. 2000: 546. ISBN 3-88763-075-0.
- ^ Dictionary of organic compounds. London: Chapman & Hall. 1996: 3877. ISBN 0-412-54090-8.
- ^ FAURBYE A, JACOBSEN O, KRISTJANSEN P, MUNKVAD I. Imipramine-N-oxide: preliminary investigation of a new antidepressive drug. The American Journal of Psychiatry. September 1963, 120 (3): 277–8 [2023-11-21]. PMID 13944543. doi:10.1176/ajp.120.3.277. (原始内容存档于2019-12-10).
- ^ Lingjaerde O. [Imiprex "Dumex" (imipramine oxide). A new tricyclic antidepressive agent]. Tidsskrift for den Norske Lægeforening. November 1971, 91 (31): 2267–8. PMID 5133241 (挪威语).
外部链接
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