非诺特罗
-_and_(SS)-_fenoterol.svg) | |
 | |
| 临床资料 | |
|---|---|
| AHFS/Drugs.com | Micromedex详细消费者药物信息 |
| 给药途径 | Inhalation (MDI) |
| ATC码 | |
| 法律规范状态 | |
| 法律规范 |
|
| 药物动力学数据 | |
| 生物半衰期 | 6.5小时左右 [1][2][3][4] |
| 识别信息 | |
| |
| CAS号 | 13392-18-2  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.205.960 |
| 化学信息 | |
| 化学式 | C17H21NO4 |
| 摩尔质量 | 303.35 g/mol |
| 3D模型（JSmol） | |
| |
| |
非诺特罗（Fenoterol） 是一种用来扩张呼吸道的β2肾上腺素受体激动药。非诺特罗 属于拟交感神经药 β2 刺激剂和气喘药。
非诺特罗 由勃林格殷格翰制造和销售，商品名称为：Berotec N （备劳喘）。制造商有时也会把非诺特罗与ipratropium混和后销售，商品名称为 Berodual N （备喘全）。
医学用途
非诺特罗 是短效的 β2刺激剂。当非诺特罗使用超过建议的医疗用剂量（每日最多只能吸入八剂、每剂量需间隔至少五分钟，若气喘状况没好转，则再吸入第二剂[5]）时，也会成为β1 受体刺激剂。
使用者可以于运动前吸入一剂，预防稍后因运动所诱发的气喘（气管痉挛）。[6]
副作用
已知曾有患者在急性气喘发作时吸入了高达80剂的非诺特罗，最终因而死亡。当患者发现非诺特罗已经无法缓解气喘时，应当停止吸入非诺特罗，并尽快就医。[7][8]
参见
文献来源
- ^ Fenoterol Hydrobromide Drug Information, Professional. Drugs.com. 1996-01-01 [2018-06-11]. （原始内容存档于2019-08-25）.
- ^ Fenoterol - Drug Monograph. DrugInfoSys.com. 2016-10-27 [2018-06-11]. （原始内容存档于2020-11-27）.
- ^ Berotec Inhalation Solution (Fenoterol HBr). RxMed.com. [2018-06-11]. （原始内容存档于2021-04-20）.
- ^ Svedmyr, Nils. Fenoterol: A Beta2-adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy (Wiley). 1985-05-06, 5 (3): 109–126. ISSN 0277-0008. doi:10.1002/j.1875-9114.1985.tb03409.x.
- ^ Berotec N/Concise Prescribing Info/Full Prescribing info. 2018-02-28 [2018-02-28]. （原始内容存档于2020-11-23）.
Dosage / Direction for Use：
Acute Asthma Episodes: 1 puff is sufficient for prompt symptom relief in most cases, if breathing has not noticeably improved after 5 minutes, a second dose may be taken, up to a maximum of 8 puffs per day. If an attack has not been relieved by 2 puffs, further puffs may be required. In this situation, patients should consult the doctor or the nearest hospital immediately. (See Precautions).
Prophylaxis of Exercise Induced Asthma: 1-2 puffs prior to exercise, up to a maximum of 8 puffs per day.
Bronchial Asthma and Other Conditions with Reversible Airways Narrowing: If repeated dosing is required, 1-2 puffs for each administration, up to a maximum of 8 puffs per day. - ^ Management of acute exacerbations of asthma in adults. UpToDate. [2018-06-25]. （原始内容存档于2018-06-25）.
- ^ Beasley R, Pearce N, Crane J, Burgess C. Withdrawal of 非诺特罗 and the end of the New Zealand asthma mortality epidemic. International Archives of Allergy and Immunology. 1995, 107 (1-3): 325–7. PMID 7613161. doi:10.1159/000237016.
- ^ Spitzer WO, Suissa S, Ernst P, et al. The use of beta-agonists and the risk of death and near death from asthma. The New England Journal of Medicine. February 1992, 326 (8): 501–6. PMID 1346340. doi:10.1056/NEJM199202203260801.