CXCL9

CXCL9
识别号
别名	CXCL9；, CMK, Humig, MIG, SCYB9, crg-10, C-X-C motif chemokine ligand 9
外部ID	OMIM：601704 MGI：1352449 HomoloGene：1813 GeneCards：CXCL9
基因位置（人类）
染色体	4号染色体
终止	76,007,509 bp
基因位置（小鼠）
染色体	小鼠5号染色体
终止	92,475,938 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 细胞因子活性; • CXCR3 chemokine receptor binding; • chemokine activity; • 血浆蛋白结合;
细胞组分	• 细胞外区域; • external side of plasma membrane; • 细胞外空间; • 胞内;
生物学过程	• G protein-coupled receptor signaling pathway; • chemokine-mediated signaling pathway; • cell-cell signaling; • positive regulation of release of sequestered calcium ion into cytosol; • positive regulation of cAMP-mediated signaling; • 趋化性; • positive regulation of leukocyte chemotaxis; • cellular defense response; • positive regulation of myoblast fusion; • response to lipopolysaccharide; • regulation of cell population proliferation; • positive regulation of myoblast differentiation; • defense response to virus; • 免疫反应; • 信号转导; • defense response; • inflammatory response; • T cell chemotaxis; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • response to bacterium; • neutrophil chemotaxis; • leukocyte chemotaxis; • cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
直系同源
	4283
	17329
	ENSG00000138755
	ENSMUSG00000029417
	Q07325
	P18340
	NM_002416
	NM_008599
	NP_002407
	NP_032625
	维基数据
查看/编辑人类	查看/编辑小鼠

CXCL9（英语：Chemokine (C-X-C motif) ligand 9）是一小分子的细胞因子属于CXC趋化因子家族，又被称作“干扰素伽玛诱导的单核细胞因子”（Monokine induced by gamma interferon, MIG）^[5] 。CXCL9是T细胞趋化因子^[5] 。干扰素伽玛诱导CXCL9的表达。人类的CXCL9与CXCL10，CXCL11的基因相邻聚集在第四染色体上^[6] 。CXCL9，CXCL10, CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用^[7]^[8] 。

参见

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000138755 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000029417 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM. Human Mig chemokine: biochemical and functional characterization. J Exp Med. 1995 Nov 1;182(5):1301-14.
^ Lee HH, Farber JM. Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster". Cytogenet Cell Genet. 1996;74(4):255-8.
^ Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
^ Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

外部链接

Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（页面存档备份，存于互联网档案馆）

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000138755 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000029417 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[liao-5] 5.0 ^5.1 Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM. Human Mig chemokine: biochemical and functional characterization. J Exp Med. 1995 Nov 1;182(5):1301-14.

[6] Lee HH, Farber JM. Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster". Cytogenet Cell Genet. 1996;74(4):255-8.

[7] Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.

[8] Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

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