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Daf-2

维基百科,自由的百科全书
abnormal dauer formation protein 2
标识
生物 Caenorhabditis elegans
符号 daf-2
Entrez 175410
RefSeq (mRNA) NM_065249.5
RefSeq (蛋白质) NP_497650.4
UniProt Q968Y9
其他数据
染色体 III: 2.99 - 3.03 Mb

DAF-2秀丽隐杆线虫Caenorhabditis elegans)的一个基因,编码的蛋白与人胰岛素样生长因子1受体(IGF-1R)同源。DAF-2是第一个发现的与老化速率有关的代谢途径基因[1]。DAF-2也与生殖发育的调控,氧化应激的应对,温度耐受,缺氧以及对细菌病原体的抵抗有关[2]辛西娅·凯尼恩(Cynthia Kenyon)获得的DAF-2突变体线虫寿命为普通线虫的两倍[3]

参考文献

  1. ^ Keyton, C. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.
  2. ^ Minaxi S Gami and Catherine A Wolkow (2006).
  3. ^ Jennie B. Dorman, Bella Albinder, Terry Shroyer & Cynthia Kenyon, "The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans," Genetics, volume 141, number 4, pages 1399-1406 (1995); and Javier Apfeld & Cynthia Kenyon, "Cell non-autonomy of C. elegans daf-2 function in the regulation of diapause and lifespan," Cell, v. 95, n.2, pp.199-210 (1998).