醋氨苯砜
临床资料 | |
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商品名 | Rodilone Hansolar |
ATC码 |
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识别信息 | |
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CAS号 | 77-46-3 |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.936 |
化学信息 | |
化学式 | C16H16N2O4S |
摩尔质量 | 332.37 g·mol−1 |
3D模型(JSmol) | |
熔点 | 290 °C(554 °F) |
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醋氨苯砜(英语:Acedapsone)是一种抗菌药物,也具有抗疟活性。
醋氨苯砜是双乙酰氨苯砜的INN名。其于1937年由埃内斯特·富尔诺和他的团队在巴斯德研究所药物化学实验室合成开发,[1]并由罗纳-普朗克公司以Rodilone的名称上市销售。[2]
它从乙醚中结晶为浅黄色针状,从稀乙醇中结晶为小叶状。它微溶于水。[来源请求]
合成
醋氨苯砜可通过氨苯砜的乙酰化方便地制备。
参考资料
- ^ Fourneau E, Tréfouël J, Nitti F, Bovet D. Chimiothérapie de l'infection pneumococcique par la di-(p-acétylaminophényl)-sulfone (1399 F). Compt. Rend. Acad. Sci. July 1937, 205: 299 (法语).
- ^ Fourneau JP. Ernest Fourneau, fondateur de la chimie thérapeutique française: feuillets d'album.. Revue d'Histoire de la Pharmacie. 1987, 75 (275): 335–55. doi:10.3406/pharm.1987.2904 (法语).
- ^ Shaw IN, Christian M, Jesudasan K, Kurian N, Rao GS. Effectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity. Leprosy Review. June 2003, 74 (2): 141–7. PMID 12862255. doi:10.47276/lr.74.2.141 .
- ^ Elslager EF, Gavrilis ZB, Phillips AA, Worth DF. Repository drugs. IV. 4',4'''-Sulfonylbisacetanilide (Acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and antileprotic action. Journal of Medicinal Chemistry. May 1969, 12 (3): 357–63. PMID 4892242. doi:10.1021/jm00303a003.
- ^ Raiziss GW, Clemence LW, Severac M, Moetsch JC. Chemistry and Chemotherapy of 4,4′-Diaminodiphenylsulfone, 4-Amino-4′-hydroxy-diphenylsulfone and Related Compounds. Journal of the American Chemical Society. 1939, 61 (10): 2763–2765. doi:10.1021/ja01265a060.
- ^ Fromm E, Wittmann J. Derivate desp-Nitrothiophenols. Berichte der Deutschen Chemischen Gesellschaft. 1908, 41 (2): 2264–2273. doi:10.1002/cber.190804102131.