BxPC-3细胞

BxPC-3 (BxPC3）是用于研究胰腺癌及其治疗方法的人类胰腺癌细胞系。BxPC-3细胞是在1986年从一个已61岁的人类女性体内获得，并且被证实在无胸腺裸鼠中具有致瘤性，具有中等分化能力^[1]，同时又会产生粘蛋白，并且表现出上皮组织形态。BxPC-3细胞不会发生在胰腺癌中常见的KRAS（英语：KRAS）突变^[2]。BcPC-3细胞和JoPaca-1细胞均有高表达的癌干细胞标志物（英语：Stem cell marker）^[3]。BxPC-3目前已用于致瘤研究、胰腺癌治疗研究及其他生物医学应用中。由于细胞可帮助胰腺癌药物的开发，因此有学者对细胞的表型和基因型特性进行研究，特别是因为BxPC-3细胞具有血管生成因子IL-8、血管内皮生长因子和前列腺素E2的高度表达，故而可以作为潜在的药物靶标^[4]。

参考资料

^ Tan, MH; Nowak, NJ; Loor, R; Ochi, H; Sandberg, AA; Lopez, C; Pickren, JW; Berjian, R; Douglass HO, Jr; Chu, TM. Characterization of a new primary human pancreatic tumor line.. Cancer investigation. 1986, 4 (1): 15–23 [2019-11-25]. PMID 3754176. doi:10.3109/07357908609039823.
^ Berrozpe, G; Schaeffer, J; Peinado, MA; Real, FX; Perucho, M. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.. International journal of cancer. 1994-07-15, 58 (2): 185–91 [2019-11-25]. PMID 8026879. doi:10.1002/ijc.2910580207.
^ Fredebohm, J; Boettcher, M; Eisen, C; Gaida, MM; Heller, A; Keleg, S; Tost, J; Greulich-Bode, KM; Hotz-Wagenblatt, A; Lathrop, M; Giese, NA; Hoheisel, JD. Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.. PloS one. 2012, 7 (11): e48503 [2019-11-25]. PMID 23152778. doi:10.1371/journal.pone.0048503.
^ Deer, EL; González-Hernández, J; Coursen, JD; Shea, JE; Ngatia, J; Scaife, CL; Firpo, MA; Mulvihill, SJ. Phenotype and genotype of pancreatic cancer cell lines.. Pancreas. 2010-05, 39 (4): 425–35 [2019-11-25]. PMID 20418756. doi:10.1097/MPA.0b013e3181c15963.

[1] Tan, MH; Nowak, NJ; Loor, R; Ochi, H; Sandberg, AA; Lopez, C; Pickren, JW; Berjian, R; Douglass HO, Jr; Chu, TM. Characterization of a new primary human pancreatic tumor line.. Cancer investigation. 1986, 4 (1): 15–23 [2019-11-25]. PMID 3754176. doi:10.3109/07357908609039823.

[2] Berrozpe, G; Schaeffer, J; Peinado, MA; Real, FX; Perucho, M. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.. International journal of cancer. 1994-07-15, 58 (2): 185–91 [2019-11-25]. PMID 8026879. doi:10.1002/ijc.2910580207.

[3] Fredebohm, J; Boettcher, M; Eisen, C; Gaida, MM; Heller, A; Keleg, S; Tost, J; Greulich-Bode, KM; Hotz-Wagenblatt, A; Lathrop, M; Giese, NA; Hoheisel, JD. Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.. PloS one. 2012, 7 (11): e48503 [2019-11-25]. PMID 23152778. doi:10.1371/journal.pone.0048503.

[4] Deer, EL; González-Hernández, J; Coursen, JD; Shea, JE; Ngatia, J; Scaife, CL; Firpo, MA; Mulvihill, SJ. Phenotype and genotype of pancreatic cancer cell lines.. Pancreas. 2010-05, 39 (4): 425–35 [2019-11-25]. PMID 20418756. doi:10.1097/MPA.0b013e3181c15963.

[1]

[2]

[3]

[4]