利卡司瓊
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臨床資料 | |
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ATC碼 |
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識別資訊 | |
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CAS號 | 117086-68-7 ![]() |
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ChemSpider | |
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化學資訊 | |
化學式 | C19H27N3O |
摩爾質量 | 313.45 g·mol−1 |
3D模型(JSmol) | |
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利卡司瓊(INN:ricasetron;開發代號:BRL-46470) 是一種藥物,用作血清素5-HT3受體的選擇性拮抗劑。[1]它與其他5-HT3拮抗劑一樣具有止吐作用,[2]並且具有明顯強於其他相關藥物的抗焦慮作用,[3]且副作用比苯二氮䓬類抗焦慮藥更少。[4][5]然而,它從未被開發用於醫療用途。
參考資料
- ^ Newberry NR, Watkins CJ, Sprosen TS, Blackburn TP, Grahame-Smith DG, Leslie RA. BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors. Neuropharmacology. August 1993, 32 (8): 729–35. PMID 8413836. S2CID 19469831. doi:10.1016/0028-3908(93)90180-B.
- ^ Bermudez J, Sanger GJ. Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets. The Journal of Pharmacy and Pharmacology. June 1994, 46 (6): 520–1. PMID 7932054. S2CID 11799269. doi:10.1111/j.2042-7158.1994.tb03843.x.
- ^ Blackburn TP, Baxter GS, Kennett GA, King FD, Piper DC, Sanger GJ, Thomas DR, Upton N, Wood MD. BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties. Psychopharmacology. 1993, 110 (3): 257–64. PMID 7831418. S2CID 9595942. doi:10.1007/BF02251279.
- ^ Link CG, Leigh TJ, Dennison JK. The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG. British Journal of Clinical Pharmacology. April 1993, 35 (4): 395–9. PMC 1381550
. PMID 8485019. doi:10.1111/j.1365-2125.1993.tb04156.x.
- ^ de Souza Silva M, Guimarães FS, Graeff FG, Tomaz C. Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam. Behavioural Brain Research. December 1993, 59 (1–2): 141–5. PMID 8155281. S2CID 3999586. doi:10.1016/0166-4328(93)90160-R.
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