組織蛋白去乙醯酶抑制劑
組織蛋白去乙醯酶抑制劑(英語：HDAC inhibitor，簡寫HDI或HDAC抑制劑)是一種透過抑制身體內組織蛋白去乙醯酶功能的藥物類別，亦存在於胎兒及花椒內。現時有健康食品生產商建議透過進食花椒油而達至防癌的功效。
現時醫學界有研究透過「組織蛋白去乙醯酶抑制劑」來治療癌症[1]及神經退行性疾病(neurodegenerative diseases)。這些抑制劑的具體機制，例如有關的化合物如何達到有關的功效，到現在還未清楚。不過，有關文獻亦有提出可能的表觀遺傳學途徑[2] Richon et al.[3]發現HDAC抑制劑可以透過引導p21 (WAF1)來調節p53的腫瘤抑制功能[4]。對於 HDAC 抑制劑如何調控基因表達 ，目前已有比較大的進展。持續的研究 HDAC 抑制劑的調節基因機制，將快速促進新藥設計及生物標記的鑑定 [5]。
參考
- ^ Marks PA, Dokmanovic M. Histone deacetylase inhibitors: discovery and development as anticancer agents. Expert opinion on investigational drugs. 2005, 14 (12): 1497–511. PMID 16307490. doi:10.1517/13543784.14.12.1497.
- ^ Claude Monneret. Histone deacetylase inhibitors for epigenetic therapy of cancer. Anticancer Drugs. April 2007, 18: 363–70.
- ^ Richon VM, Sandhoff TW, Rifkind RA, Marks PA. AUG 29 2000. "Histone deacetylase inhibitor selectively induces p21(WAF1) expression and gene-associated histone acetylation." Proceedings of the National Academy of Sciences of the United States of America 97(18):10014-10019.
- ^ el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. NOV 19 1993. "WAF1, a potential mediator of p53 tumor suppression." Cell 75(4):817-25.
- ^ Chueh, Anderly C.; Tse, Janson W.T.; Tögel, Lars; Mariadason, John M. Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells. Antioxidants & Redox Signaling. 2014-02-10, 23 (1): 66–84. ISSN 1523-0864. PMC 4492771
. PMID 24512308. doi:10.1089/ars.2014.5863.
