七葉皂苷
β-七葉皂苷(主要成分) | |
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IUPAC名 β-D-Glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-(22α-(acetyloxy)-16α,24,28-trihydroxy-21β-{[(2Z)-2-methylbut-2-enoyl]oxy}olean-12-en-3β-yl β-D-glucopyranosiduronic acid) | |
系統名 (2S,3S,4S,5R,6R)-6[(3S,4S,4aR,6aR,6bS,8R,8aR,9R,10R,12aS,14aR,14bR)-9-(Acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10[(2Z)-2-methylbut-2-enoyl]oxy1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy4-hydroxy-3,5-bis{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxane-2-carboxylic acid | |
別名 | Escin |
識別 | |
CAS號 | 6805-41-0(Aescin) ![]() 11072-93-8(β-Aescin) ![]() |
PubChem | 6476031 |
ChemSpider | 4977652 |
SMILES |
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InChI |
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InChIKey | AXNVHPCVMSNXNP-OXPBSUTMBO |
KEGG | C08921 |
性質 | |
化學式 | C55H86O24 |
摩爾質量 | 1131.26 g·mol−1 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
七葉皂苷(英語:Aescin)是歐洲七葉樹中發現的具有抗炎、血管收縮和血管保護作用的皂苷混合物。七葉皂苷是歐洲七葉樹的主要活性成分,具有其大部分藥用特性。七葉皂苷的主要活性化合物是β-七葉皂苷,此外還含有其他成分,包括α-七葉皂苷、原七葉皂苷元、玉蕊醇、cryptoescin和苯並吡喃酮。[1]
有證據表明七葉皂苷,尤其是純β-七葉皂苷,是短期治療慢性靜脈功能不全的安全有效的藥物;[2][3]然而,需要更多高質量的隨機對照試驗來證實其有效性。[3]歐洲七葉樹提取物可能與使用壓力襪一樣有效且耐受性良好。[3]
作用機制
七葉皂苷似乎通過多種機制產生作用。它通過增強內皮細胞對鈣離子的滲透性來誘導內皮一氧化氮的合成,並誘導前列腺素F2α的釋放。[4][5][6]其他可能的機制包括血清素拮抗作用和組胺拮抗作用以及組織黏多糖分解代謝的減少。[4]
參考資料
- ^ Ramelet, Albert-Adrien. Venoactive Drugs. Sclerotherapy: treatment of varicose and telangiectatic leg veins 6th. Elsevier Science Health Science. 24 November 2016: 426–434. ISBN 978-0-323-37726-3.
- ^ Goldman, Mitchel P. Sclerotherapy : treatment of varicose and telangiectatic leg veins. Weiss, Robert A.,, Guex, Jean-Jerome 6th. Amsterdam: Elsevier Science Health Science. 2016. ISBN 978-0-323-37727-0. OCLC 959274899.
- ^ 3.0 3.1 3.2 Pittler, Max H.; Ernst, Edzard. Horse chestnut seed extract for chronic venous insufficiency. The Cochrane Database of Systematic Reviews. 2012-11-14, 11 (11): CD003230. ISSN 1469-493X. PMC 7144685
. PMID 23152216. doi:10.1002/14651858.CD003230.pub4.
- ^ 4.0 4.1 Sirtori CR. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Pharmacol. Res. September 2001, 44 (3): 183–193. PMID 11529685. doi:10.1006/phrs.2001.0847.
- ^ Carrasco OF, Vidrio H. Endothelium protectant and contractile effects of the antivaricose principle escin in rat aorta. Vascul. Pharmacol. July 2007, 47 (1): 68–73. PMID 17512261. doi:10.1016/j.vph.2007.04.003.
- ^ Berti F, Omini C, Longiave D. The mode of action of aescin and the release of prostaglandins. Prostaglandins. August 1977, 14 (2): 241–249. PMID 897216. doi:10.1016/0090-6980(77)90169-1.
外部連結
- Information on horse chestnut extract (頁面存檔備份,存於互聯網檔案館) from Memorial Sloan-Kettering Cancer Center
- CID 76967409 from PubChem - alpha-Aescin