1-(2-聯苯基)哌嗪

**1-(2-聯苯基)哌嗪**
識別資訊
	IUPAC命名法 1-(2-diphenyl)piperazine; ;
CAS號	180698-18-4
PubChem CID	2737389;
ChemSpider	2019031 ;
UNII	T5S5265H6V;
ChEMBL	ChEMBL494675 ;
化學資訊
化學式	C16H18N2
摩爾質量	238.33 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C3CNCCN3c1ccccc1-c2ccccc2;
	InChI InChI=1S/C16H18N2/c1-2-6-14(7-3-1)15-8-4-5-9-16(15)18-12-10-17-11-13-18/h1-9,17H,10-13H2 ; Key:RKRVRTJVCWZOQS-UHFFFAOYSA-N ;

1-(2-聯苯基)哌嗪是一種有機化合物，化學式為C₁₆H₁₈N₂。它可由1-叔丁氧羰基-4-(2-溴苯基)哌嗪和苯硼酸在四(三苯基膦)鈀催化下反應製得，^[1]或由2-氨基聯苯和二(氯乙基)胺鹽酸鹽在碳酸鉀和碘化鉀存在下反應得到。^[2]它和N-苄基-6-溴己酰胺在碳酸鉀存在下於乙腈中回流反應，可以得到N-苄基-(4-聯苯-2-基)哌嗪己酰胺。^[3]

參考文獻

^ Yu, Maolin; Daniels, Matthew H.; Harmange, Jean-Christophe P.; Tibbitts, Thomas T.; Ledeboer, Mark W.; Walsh, Liron; Mundel, Peter H.; Malojcic, Goran. Pyridazinone derivatives in the treatment of disease and their preparation. 2019 WO 2019055966 A2.
^ Stefania Porcu, Stefania Demuro, Alberto Luridiana, Andrea Cocco, Angelo Frongia, David J. Aitken, Florence Charnay-Pouget, Regis Guillot, Giorgia Sarais, Francesco Secci. Brønsted Acid Mediated Cascade Reaction To Access 3-(2-Bromoethyl)benzofurans. Organic Letters. 2018-12-07, 20 (23): 7699–7702 [2022-03-05]. ISSN 1523-7060. doi:10.1021/acs.orglett.8b03429. （原始內容存檔於2022-03-05）（英語）.
^ Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Claudia Fracasso, Sara Guzzetti, Silvio Caccia, Marialessandra Contino, Nicola A. Colabufo, Francesco Berardi, Roberto Perrone. Structural Modifications of N -(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-piperazinehexanamides: Influence on Lipophilicity and 5-HT 7 Receptor Activity. Part III. Journal of Medicinal Chemistry. 2008-09-25, 51 (18): 5813–5822 [2022-03-05]. ISSN 0022-2623. doi:10.1021/jm800615e. （原始內容存檔於2022-03-05）（英語）.

[1] Yu, Maolin; Daniels, Matthew H.; Harmange, Jean-Christophe P.; Tibbitts, Thomas T.; Ledeboer, Mark W.; Walsh, Liron; Mundel, Peter H.; Malojcic, Goran. Pyridazinone derivatives in the treatment of disease and their preparation. 2019 WO 2019055966 A2.

[2] Stefania Porcu, Stefania Demuro, Alberto Luridiana, Andrea Cocco, Angelo Frongia, David J. Aitken, Florence Charnay-Pouget, Regis Guillot, Giorgia Sarais, Francesco Secci. Brønsted Acid Mediated Cascade Reaction To Access 3-(2-Bromoethyl)benzofurans. Organic Letters. 2018-12-07, 20 (23): 7699–7702 [2022-03-05]. ISSN 1523-7060. doi:10.1021/acs.orglett.8b03429. （原始內容存檔於2022-03-05）（英語）.

[3] Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Claudia Fracasso, Sara Guzzetti, Silvio Caccia, Marialessandra Contino, Nicola A. Colabufo, Francesco Berardi, Roberto Perrone. Structural Modifications of N -(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-piperazinehexanamides: Influence on Lipophilicity and 5-HT 7 Receptor Activity. Part III. Journal of Medicinal Chemistry. 2008-09-25, 51 (18): 5813–5822 [2022-03-05]. ISSN 0022-2623. doi:10.1021/jm800615e. （原始內容存檔於2022-03-05）（英語）.

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