LY-272,015
臨床資料 | |
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其他名稱 | LY-272,015; 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole |
識別資訊 | |
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CAS號 | 172895-15-7 |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
化學資訊 | |
化學式 | C21H24N2O2 |
摩爾質量 | 336.44 g·mol−1 |
3D模型(JSmol) | |
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LY-272,015是一種有機化合物,化學式為C21H24N2O2,屬於β-咔啉衍生物,能作為血清素受體5-HT2B的拮抗劑,由禮來公司作為高血壓藥物研發[1][2]。
參考文獻
- ^ Watts SW, Fink GD. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. The American Journal of Physiology. March 1999, 276 (3): H944–52. PMID 10070078. S2CID 13301249. doi:10.1152/ajpheart.1999.276.3.H944.
- ^ Russell A, Banes A, Berlin H, Fink GD, Watts SW. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat. The Journal of Pharmacology and Experimental Therapeutics. October 2002, 303 (1): 179–87. PMID 12235249. S2CID 98055109. doi:10.1124/jpet.102.037390.