VUAA1
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VUAA1 | |
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IUPAC名 N-(4-Ethylphenyl)-2-{[4-ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide | |
識別 | |
CAS編號 | 525582-84-7 ![]() |
PubChem | 1319135 |
ChemSpider | 1105882 |
SMILES |
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性質 | |
化學式 | C19H21N5OS |
摩爾質量 | 367.47 g·mol−1 |
危險性 | |
GHS危險性符號![]() | |
GHS提示詞 | Warning |
H-術語 | H315, H319, H335 |
P-術語 | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
VUAA1是一種昆蟲嗅覺共受體激動劑型驅蟲劑[1][2]。由美國范德比爾特大學與比爾及梅琳達·蓋茨基金會部分資助下發現[3][4]。
VUAA1被認為是通過強力刺激昆蟲嗅覺受體來實現驅蟲效果,且效力約為避蚊胺的1000倍[5],並可能導致「開創一個強大的新驅蟲劑類型,用於消滅有害昆蟲、農業害蟲和病媒等的破壞行為」[6]。
VUAA1還展示出刺激蚊子精子活力的特性,從而表明蚊子的嗅覺和繁殖之間的聯繫[7]。
參考文獻
- ^ Medicine, Vanderbilt University School of. Allosteric antagonism of insect odorant receptor ion channels. | Chemical Synthesis Core. medschool.vanderbilt.edu. [2016-06-02].
- ^ 向婧潔、鍾延強、樊莉、魯瑩. 蚊虫驱避剂新进展. 中國媒介生物學及控制雜誌. 2013, 24 (1): 79–82.
- ^ Jones, P. L.; Pask, G. M.; Rinker, D. C.; Zwiebel, L. J. Functional agonism of insect odorant receptor ion channels. Proceedings of the National Academy of Sciences. 2011, 108 (21): 8821–5. Bibcode:2011PNAS..108.8821J. PMC 3102409
. PMID 21555561. doi:10.1073/pnas.1102425108
.
- ^ Doug Gross. A bug repellent that could save lives - CNN.com. CNN. 5 May 2014 [2016-06-02].
- ^ New type of insect repellent may be thousands of times stronger than DEET (新聞稿). physorg.com. May 9, 2011.
- ^ Functional agonism of insect odorant receptor ion channel (PDF) (新聞稿). April 4, 2011.
- ^ VICB Article: Sulfilimine Cross-Links A Key to Tissue Evolution. www.vanderbilt.edu. [2016-06-02].