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乳腺生長

維基百科,自由的百科全書
乳腺生長
Mammoplasia
妊娠階段乳房會自然增大
分類和外部資源
ICD-10N62
ICD-9-CM611.1
[編輯此條目的維基數據]

乳腺生長(mammoplasia)又稱乳腺增生乳腺增殖症,是乳房正常或自發的增大[1]。乳腺生長一般會出生在女性的青春期妊娠階段,在月經週期中特定階段也會有乳房增大的情形[2][3][4]。若是男性乳腺生長,會視為是疾病,稱為男性乳房發育症[4]。若是女性乳腺異常生長的情形,會稱為巨乳症(或是乳房肥大症),也會視為是疾病[5][6][7]

乳腺生長可能是因為和乳房製造及儲存母乳而產生的暫時性乳房膨脹英語breast engorgement有關,這多半是和哺乳及/或乳溢症(過度或是不正常的母乳製造)相關[8]。乳腺生長也常伴隨着乳房疼痛[9][10]

在月經週期中的黃體期,因為高濃度的雌激素及/或孕酮造成的乳房血流量增加及/或月經前水瀦留英語Premenstrual water retention,乳房的體積會暫時性的增大,女性會有乳房沉重、腫脹和刺痛的感覺[11][12]

乳腺生長也可能是許多藥物的效果或是副作用,例如雌激素[2][13]、像螺內酯[14]醋酸環丙孕酮[15]比卡魯胺英語bicalutamide[16][17]非那斯特萊[18][19]抗雄激素生長激素[20][21]以及會提高體內催乳素的藥物,例如D2受體拮抗劑,像是維思通抗精神病藥甲氧氯普胺多潘立酮[22][23],以及像選擇性5-羥色胺再攝取抑制劑(SSRI)及三環類抗抑鬱藥(TCA)之類的抗抑鬱藥[23][24][25]。若是使用文拉法辛之類的5-羥色胺和去甲腎上腺素再攝取抑制劑(SNRI),這類的風險會比較小[26]。非典型的抗抑鬱藥米氮平安非他酮不會提高體內催乳素濃度(安非他酮反而會降低催乳素濃度),因此使用這類藥物就沒有會使乳腺生長的風險[22]。其他和乳腺生長有關的藥物包括D-青黴胺英語D-penicillamine布西拉明英語bucillamineneothetazone英語neothetazone環孢素英地那韋英語indinavir大麻西咪替丁[6][27]

1997的一個研究發現,在其研究的59名女性中,有23名(39%)發現有出現使用SSRI及和乳腺生長的相關性[26]。研究也發現SSRI和乳溢症之間有相關性[24][28][29][30]。這些副作用可能因為藥物造成的高催乳素血症英語hyperprolactinemia,這個效果可能因為抑制催乳素分泌的結節漏斗英語tuberoinfundibular多巴胺致能英語Dopaminergic神經元,因為血清素調節而被抑制的結果[26][28][29]。值得注意的是這些藥物造成的乳腺生長也和體重增加英語Weight gain高度相關(在1997年的研究中,體重增加中的人中有83%也有乳腺生長,而體重沒有增加的人之中,只有30%有乳腺生長)[26]。這些伴隨着SSRI用藥出現的乳腺生長,在停藥後是可以復原的[30]。 SSRI和乳癌風險的增加有關[31],這個現象符合高催乳素和高乳癌風險有關的事實[32][33]

若是針對女性青春期誘導英語puberty induction而進行的激素替代療法(HRT)、跨性別女性進行的性別肯定激素治療(GAHT),或者是荷爾蒙豐胸英語Hormonal breast enhancement,都會希望出現乳腺生長的結果[34][35]

參考資料

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