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依諾替庫單抗

維基百科,自由的百科全書
依諾替庫單抗
單株抗體
種類完整抗體
目標DLL4英語DLL4
臨床資料
其他名稱依諾蘇單抗、REGN421
ATC碼
  • 未分配
識別資訊
CAS號1192578-27-0
ChemSpider
  • none
UNII
KEGG

依諾替庫單抗INN:Enoticumab;開發代號:REGN421),或譯依諾蘇單抗,是一種全人IgG1英語IGHG1單株抗體,可結合人DLL4英語DLL4並破壞Notch介導的信號傳導。該藥物充當免疫調節劑[1][2][3][4][5]

參考資料

  1. ^ World Health Organization. International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 107 (PDF). WHO Drug Information. 2012, 26 (2) [2024-01-20]. (原始內容存檔 (PDF)於2016-03-04). 
  2. ^ Huang J, Hu W, Hu L, Previs RA, Dalton HJ, Yang XY, Sun Y, McGuire M, Rupaimoole R, Nagaraja AS, Kang Y, Liu T, Nick AM, Jennings NB, Coleman RL, Jaffe RB, Sood AK. Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth. Mol. Cancer Ther. June 2016, 15 (6): 1344–52. PMC 4893925可免費查閱. PMID 27009216. doi:10.1158/1535-7163.MCT-15-0144. 
  3. ^ Kuhnert F, Chen G, Coetzee S, Thambi N, Hickey C, Shan J, Kovalenko P, Noguera-Troise I, Smith E, Fairhurst J, Andreev J, Kirshner JR, Papadopoulos N, Thurston G. Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer. Cancer Res. October 2015, 75 (19): 4086–96. PMID 26377940. doi:10.1158/0008-5472.CAN-14-3773可免費查閱. 
  4. ^ Chiorean EG, LoRusso P, Strother RM, Diamond JR, Younger A, Messersmith WA, Adriaens L, Liu L, Kao RJ, DiCioccio AT, Kostic A, Leek R, Harris A, Jimeno A. A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors. Clin. Cancer Res. June 2015, 21 (12): 2695–703. PMID 25724527. doi:10.1158/1078-0432.CCR-14-2797可免費查閱. 
  5. ^ Miles KM, Seshadri M, Ciamporcero E, Adelaiye R, Gillard B, Sotomayor P, Attwood K, Shen L, Conroy D, Kuhnert F, Lalani AS, Thurston G, Pili R. Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts. PLOS ONE. 2014, 9 (11): e112371. Bibcode:2014PLoSO...9k2371M. PMC 4231048可免費查閱. PMID 25393540. doi:10.1371/journal.pone.0112371可免費查閱.