1,4-二(三氟甲基)苯

1,4-二(三氟甲基)苯
別名	對二三氟甲苯; α,α,α,α',α',α'-六氟對二甲苯
識別
CAS號	433-19-2
SMILES	FC(F)(F)c1ccc(cc1)C(F)(F)F;
性質
化學式	C8H4F6
摩爾質量	214.11 g·mol−1
熔點	115—117 °C（388—390 K）
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

1,4-二(三氟甲基)苯是一種有機化合物，化學式為C₈H₄F₆。它可由4-三氟甲基苯硼酸和三氟甲基亞銅（或其配合物^[2]）反應製得。^[3]三氟乙酸鈉也可作為三氟甲基化試劑與對三氟甲基碘苯反應，得到1,4-二(三氟甲基)苯。^[4]它在硫酸-三氟乙酸中回流後加入NBS反應，可以得到1,4-二溴-2,5-二(三氟甲基)苯。^[5]它和三溴化硼在四氯化碳中反應，可以得到1,4-二(三溴甲基)苯。^[6]

參考文獻

^ Yagupol'skii, L. M.; Shein, S. M.; Krasnosel'skaya, M. I.; Solodushenkov, S. N. Preparation of 2-amino-4-trifluoromethylbenzoic acid. Zhurnal Obshchei Khimii, 1965. 35 (7): 1261-1263. ISSN: 0044-460X.
^ John Wiley & Sons. E-EROS encyclopedia of reagents for organic synthesis. Hoboken, NJ. [1999]-. ISBN 978-0-470-84289-8. OCLC 48998476. 請檢查|date=中的日期值 (幫助)
^ Hiroki Serizawa, Kohsuke Aikawa, Koichi Mikami. Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation. Chemistry - A European Journal. 2013-12-23, 19 (52): 17692–17697 [2020-10-22]. doi:10.1002/chem.201303828 （英語）.
^ Carr, G. E.; Chambers, R. D.; Holmes, T. F.; Parker, D. G. ChemInform Abstract: Sodium Perfluoroalkane Carboxylates as Sources of Perfluoroalkyl Groups.. ChemInform. 1988-07-26, 19 (30) [2022-10-01]. doi:10.1002/chin.198830124. （原始內容存檔於2022-10-04）（英語）.
^ Devic, Thomas; Horcajada, Patricia; Serre, Christian; Salles, Fabrice; Maurin, Guillaume; Moulin, Béatrice; Heurtaux, Daniela; Clet, Guillaume; Vimont, Alexandre; Grenèche, Jean-Marc; Ouay, Benjamin Le. Functionalization in Flexible Porous Solids: Effects on the Pore Opening and the Host−Guest Interactions. Journal of the American Chemical Society. 2010-01-27, 132 (3) [2020-10-22]. ISSN 0002-7863. doi:10.1021/ja9092715. （原始內容存檔於2020-10-08）（英語）.
^ Chen, Hongbiao; Yin, Jianxiang; Lin, Yuanbin. Mild and efficient conversion of trifluoromethylarenes into tribromomethylarenes using boron tribromide. Chemical Papers. 2009-01-01, 63 (1) [2022-10-01]. ISSN 1336-9075. doi:10.2478/s11696-008-0082-3. （原始內容存檔於2022-10-04）.

[1] Yagupol'skii, L. M.; Shein, S. M.; Krasnosel'skaya, M. I.; Solodushenkov, S. N. Preparation of 2-amino-4-trifluoromethylbenzoic acid. Zhurnal Obshchei Khimii, 1965. 35 (7): 1261-1263. ISSN: 0044-460X.

[2] John Wiley & Sons. E-EROS encyclopedia of reagents for organic synthesis. Hoboken, NJ. [1999]-. ISBN 978-0-470-84289-8. OCLC 48998476. 請檢查|date=中的日期值 (幫助)

[3] Hiroki Serizawa, Kohsuke Aikawa, Koichi Mikami. Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation. Chemistry - A European Journal. 2013-12-23, 19 (52): 17692–17697 [2020-10-22]. doi:10.1002/chem.201303828 （英語）.

[4] Carr, G. E.; Chambers, R. D.; Holmes, T. F.; Parker, D. G. ChemInform Abstract: Sodium Perfluoroalkane Carboxylates as Sources of Perfluoroalkyl Groups.. ChemInform. 1988-07-26, 19 (30) [2022-10-01]. doi:10.1002/chin.198830124. （原始內容存檔於2022-10-04）（英語）.

[5] Devic, Thomas; Horcajada, Patricia; Serre, Christian; Salles, Fabrice; Maurin, Guillaume; Moulin, Béatrice; Heurtaux, Daniela; Clet, Guillaume; Vimont, Alexandre; Grenèche, Jean-Marc; Ouay, Benjamin Le. Functionalization in Flexible Porous Solids: Effects on the Pore Opening and the Host−Guest Interactions. Journal of the American Chemical Society. 2010-01-27, 132 (3) [2020-10-22]. ISSN 0002-7863. doi:10.1021/ja9092715. （原始內容存檔於2020-10-08）（英語）.

[6] Chen, Hongbiao; Yin, Jianxiang; Lin, Yuanbin. Mild and efficient conversion of trifluoromethylarenes into tribromomethylarenes using boron tribromide. Chemical Papers. 2009-01-01, 63 (1) [2022-10-01]. ISSN 1336-9075. doi:10.2478/s11696-008-0082-3. （原始內容存檔於2022-10-04）.

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