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CD29

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維基百科，自由的百科全書
CD29
已知的結構
PDB直系同源搜尋: PDBe RCSB
識別號
別名ITGB1；, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
外部IDOMIM：135630 MGI：96610 HomoloGene：22999 GeneCards：ITGB1
基因位置（人類）
10號染色體
染色體10號染色體[1]
10號染色體
CD29的基因位置
CD29的基因位置
基因座10p11.22起始32,900,319 bp[1]
終止33,005,792 bp[1]
RNA表達模式
查閱更多表達數據
直系同源
物種人類小鼠
Entrez

3688

16412

Ensembl

ENSG00000150093

ENSMUSG00000025809

UniProt

P05556

P09055

mRNA​序列

NM_010578

蛋白序列

NP_002202
​NP_391988
​NP_596867

NP_034708

基因位置​（UCSC）Chr 10: 32.9 – 33.01 MbChr 8: 129.41 – 129.46 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

整聯蛋白β-1（英語：Integrin beta-1），也被稱為 CD29 是一個由人類基因 ITGB1 編碼的蛋白質[5]。CD29是整合素極晚期抗原受體的一個亞基。它與α-3亞基形成整合素α3β1，作為神經生長因子1和絡絲蛋白的受體。在心肌和骨骼肌種，整聯蛋白β-1會選擇性表達為β-1D蛋白質異形體。

相互作用

CD29已經顯示出與下列蛋白質交互作用：

參考文獻

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2. Annals of Human Genetics. Jan 1989, 53 (Pt 1): 15–22. PMID 2524991. doi:10.1111/j.1469-1809.1989.tb01118.x. 
  6. ^ Otey CA, Pavalko FM, Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. The Journal of Cell Biology. Aug 1990, 111 (2): 721–9. PMC 2116186 可免費查閱. PMID 2116421. doi:10.1083/jcb.111.2.721. 
  7. ^ Otey CA, Vasquez GB, Burridge K, Erickson BW. Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. The Journal of Biological Chemistry. Oct 1993, 268 (28): 21193–7. PMID 7691808. 
  8. ^ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. European Journal of Immunology. Mar 2000, 30 (3): 900–7. PMID 10741407. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. 
  9. ^ Radford KJ, Thorne RF, Hersey P. CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. Biochemical and Biophysical Research Communications. May 1996, 222 (1): 13–8. PMID 8630057. doi:10.1006/bbrc.1996.0690. 
  10. ^ 10.0 10.1 Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. Journal of Hepatology. Sep 2002, 37 (3): 322–30. PMID 12175627. doi:10.1016/S0168-8278(02)00175-7. 
  11. ^ Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. The Journal of Biological Chemistry. Oct 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200. 
  12. ^ 12.0 12.1 van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. The Journal of Cell Biology. Jan 2002, 156 (2): 361–76. PMC 2199218 可免費查閱. PMID 11807098. doi:10.1083/jcb.200103037. 
  13. ^ Loo DT, Kanner SB, Aruffo A. Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction. The Journal of Biological Chemistry. Sep 1998, 273 (36): 23304–12. PMID 9722563. doi:10.1074/jbc.273.36.23304. 
  14. ^ Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. The Biochemical Journal. May 1999, 340 (Pt 1): 103–11. PMC 1220227 可免費查閱. PMID 10229664. doi:10.1042/0264-6021:3400103. 
  15. ^ 15.0 15.1 Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM. Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction. Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. Nov 2002, 10 (11): 890–7. PMID 12435334. doi:10.1053/joca.2002.0842. 
  16. ^ Liliental J, Chang DD. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379. 
  17. ^ Chang DD, Wong C, Smith H, Liu J. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. The Journal of Cell Biology. Sep 1997, 138 (5): 1149–57. PMC 2136751 可免費查閱. PMID 9281591. doi:10.1083/jcb.138.5.1149. 
  18. ^ Chang DD, Hoang BQ, Liu J, Springer TA. Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. The Journal of Biological Chemistry. Mar 2002, 277 (10): 8140–5. PMID 11741908. doi:10.1074/jbc.M109031200. 
  19. ^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. Journal of Cell Science. Jul 2000, 113 (13): 2385–97. PMID 10852818. 
  20. ^ Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. Current Biology. Apr 2002, 12 (8): 622–31. PMID 11967148. doi:10.1016/S0960-9822(02)00764-9. 
  21. ^ Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. The Journal of Biological Chemistry. Jun 2002, 277 (23): 20895–902. PMID 11919189. doi:10.1074/jbc.M200200200. 
  22. ^ Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T. Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Molecular and Cellular Biology. Aug 2002, 22 (16): 5897–911. PMC 133968 可免費查閱. PMID 12138200. doi:10.1128/MCB.22.16.5897-5911.2002. 
  23. ^ Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L. Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts. Oncogene. Mar 1989, 4 (3): 325–33. PMID 2468126. 
  24. ^ Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature. 1986, 320 (6062): 531–3. PMID 2938015. doi:10.1038/320531a0. 
  25. ^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. The Journal of Biological Chemistry. Nov 1997, 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181. 
  26. ^ Han DC, Rodriguez LG, Guan JL. Identification of a novel interaction between integrin beta1 and 14-3-3beta. Oncogene. Jan 2001, 20 (3): 346–57. PMID 11313964. doi:10.1038/sj.onc.1204068. 

外部連結

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