HMOX1

Heme oxygenase (decycling) 1 血紅素加氧酶1（脫環）
PDB rendering based on 1n3u.
有效結構 PDB 直系同源檢索：PDBe, RCSB PDB查詢代碼列表 1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM
標識
代號	HMOX1; HMOX1D; HO-1; HSP32; bK286B10
擴展標識	遺傳學：141250 鼠基因：96163 同源基因：31075 ChEMBL: 2823 GeneCards: HMOX1 Gene
EC編號	1.14.99.3
基因本體論描述 分子功能 · heme oxygenase (decyclizing) activity · phospholipase D activity · signal transducer activity · enzyme binding · heme binding · protein homodimerization activity · metal ion binding 細胞成分 · extracellular space · nucleus · nucleolus · endoplasmic reticulum · endoplasmic reticulum membrane · cytosol · caveola · membrane 生物過程 · angiogenesis · endothelial cell proliferation · wound healing involved in inflammatory response · negative regulation of leukocyte migration · porphyrin-containing compound metabolic process · heme oxidation · cellular iron ion homeostasis · response to oxidative stress · intracellular protein kinase cascade · small GTPase mediated signal transduction · excretion · regulation of blood pressure · cell death · intrinsic apoptotic signaling pathway in response to DNA damage · smooth muscle hyperplasia · cellular response to nutrient · negative regulation of mast cell cytokine production · erythrocyte homeostasis · low-density lipoprotein particle clearance · response to nicotine · heme catabolic process · response to hydrogen peroxide · negative regulation of apoptotic process · positive regulation of I-kappaB kinase/NF-kappaB cascade · negative regulation of mast cell degranulation · negative regulation of DNA binding · negative regulation of sequence-specific DNA binding transcription factor activity · negative regulation of neuron apoptotic process · regulation of transcription from RNA polymerase II promoter in response to oxidative stress · response to estrogen stimulus · small molecule metabolic process · positive regulation of chemokine biosynthetic process · regulation of angiogenesis · positive regulation of angiogenesis · positive regulation of vasodilation · positive regulation of smooth muscle cell proliferation · negative regulation of smooth muscle cell proliferation · regulation of sequence-specific DNA binding transcription factor activity · protein homooligomerization · iron ion homeostasis · transmembrane transport · cellular response to cadmium ion · cellular response to hypoxia Sources: Amigo / QuickGO
RNA表達模式
更多表達數據
直系同源體
物種	人類	小鼠
Entrez	3162	15368
Ensembl	ENSG00000100292	ENSMUSG00000005413
UniProt	P09601	P14901
mRNA序列	NM_002133	NM_010442
蛋白序列	NP_002124	NP_034572
基因位置	Chr 22: 35.78 – 35.79 Mb	Chr 8: 75.09 – 75.1 Mb
PubMed查詢	[1]	[2]

血紅素加氧酶1（英語：heme oxygenase 1，縮寫HMOX1或HO-1）是一種血紅素加氧酶（EC 1.14.99.3），是血紅素代謝過程中的重要酶，它將血紅素轉化為膽綠素。

另見

• HMOX2

延伸閱讀

• Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999, 103 (1): 129–35. PMC 407858 . PMID 9884342. doi:10.1172/JCI4165. 
• Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage.. Brain. 2007, 130 (6): 1643–52. PMC 2291147 . PMID 17525142. doi:10.1093/brain/awm095. 
• Soares MP, Brouard S, Smith RN, Bach FH. Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. Immunol. Rev. 2002, 184: 275–85. PMID 12086318. doi:10.1034/j.1600-065x.2001.1840124.x. 
• Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am. J. Respir. Cell Mol. Biol. 2002, 27 (1): 8–16. PMID 12091240. doi:10.1165/ajrcmb.27.1.4862. 
• Buelow R, Tullius SG, Volk HD. Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide. Am. J. Transplant. 2002, 1 (4): 313–5. PMID 12099373. doi:10.1034/j.1600-6143.2001.10404.x. 
• Ishikawa K. Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. Curr. Pharm. Des. 2003, 9 (30): 2489–97. PMID 14529548. doi:10.2174/1381612033453767. 
• Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic. Biol. Med. 2005, 37 (8): 1097–104. PMID 15451051. doi:10.1016/j.freeradbiomed.2004.07.008. 
• Ozono R. New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. Current pharmaceutical biotechnology. 2006, 7 (2): 87–93. PMID 16724942. doi:10.2174/138920106776597630. 
• Tracz MJ, Alam J, Nath KA. Physiology and pathophysiology of heme: implications for kidney disease. J. Am. Soc. Nephrol. 2007, 18 (2): 414–20. PMID 17229906. doi:10.1681/ASN.2006080894. 
• Hill-Kapturczak N, Agarwal A. Haem oxygenase-1--a culprit in vascular and renal damage?. Nephrol. Dial. Transplant. 2007, 22 (6): 1495–9. PMID 17389623. doi:10.1093/ndt/gfm093.