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核苷三磷酸还原酶

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核苷三磷酸还原酶
Ribonucleoside-triphosphate reductase
识别码
EC编号 1.17.4.2
CAS号 9068-66-0
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum

核苷三磷酸还原酶Ribonucleoside-triphosphate reductase)(EC 1.17.4.2ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase),系统名“2-2'-脱氧核糖核苷三磷酸:硫氧还蛋白二硫键-2'-氧化还原酶”(2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase[1][2][3],系一种能催化以下化学反应的

2'-脱氧核糖核苷三磷酸+硫氧化还原蛋白二硫键+H2O 核糖核苷三磷酸+硫氧化还原蛋白

核苷三磷酸还原酶的作用需要cobamide辅酶,同时还要消耗ATP

参考

  1. ^ Blakley, R.L. Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii. J. Biol. Chem. 1965, 240: 2173–2180. PMID 14299643. 
  2. ^ Goulian, M. and Beck, W.S. Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii. J. Biol. Chem. 1966, 241: 4233–4242. PMID 5924645. 
  3. ^ Lammers, M. and Follmann, H. The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation. Struct. Bonding. 1983, 54: 27–91. doi:10.1007/bfb0111318. 

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