Macrophage mannose receptor 标志 MMR 膜蛋白数据库 56
甘露糖受体 (英语:Mannose receptor )是一类C-型凝集素 ,主要在巨噬细胞 、未成熟树突状细胞 和肝窦内皮细胞表面表达[ 1] ,在角质形成细胞 、真皮成纤维细胞 等皮肤 细胞上也有表达[ 2] 。人类基因组 中共有2个甘露糖受体基因:CD206 (甘露糖受体1型,MRC1)和CD280 (甘露糖受体2型,MRC2)。此外,甘露糖受体家族还包括CD205 、PLA2R1 [ 3] 以及CD302 [ 4] 。
甘露糖受体N-末端 富半胱氨酸 结构域(粉色)与N-乙酰半乳糖胺 (青色)结合
甘露糖受体的各个结构域[ 5]
参考文献
^ Szolnoky G, Bata-Csörgö Z, Kenderessy AS, Kiss M, Pivarcsi A, Novák Z, Nagy Newman K, Michel G, Ruzicka T, Maródi L, Dobozy A, Kemény L. A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans . Journal of Investigative Dermatology. August 2001, 117 (2): 205–13. PMID 11511295 . doi:10.1046/j.1523-1747.2001.14071.x .
^ Sheikh H, Yarwood H, Ashworth A, Isacke CM. Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. Journal of Cell Science. March 2000, 113 (6): 1021–32. PMID 10683150 . doi:10.1242/jcs.113.6.1021 .
^ East L, Isacke CM. The mannose receptor family. Biochimica et Biophysica Acta (BBA) - General Subjects. 2002, 1572 (2–3): 364–86. PMID 12223280 . doi:10.1016/S0304-4165(02)00319-7 .
^ Kato M, Khan S, d'Aniello E, McDonald KJ, Hart DN. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration . J. Immunol. November 2007, 179 (9): 6052–63. PMID 17947679 . doi:10.4049/jimmunol.179.9.6052 .
^ Taylor M, Drickamer K. Introduction to Glycobiology. Oxford University Press. 2011. ISBN 978-0-19-956911-3 .
外部链接