细胞因子释放综合征
| 细胞因子释放综合征 | |
|---|---|
| 又称 | > |
| 类型 | 药物不良反应、免疫系统疾病[*] |
| 分类和外部资源 | |
| 医学专科 | 免疫学 |
| DiseasesDB | 34296 |
| eMedicine | 2500111 |
细胞因子释放综合征（CRS）是一种全身炎症反应综合征 (SIRS)，[1][2]当免疫系统与病原体作斗争时，大量白血球被激活并释放促炎性细胞因子后，就有可能出现细胞因子释放综合征。而此时这些促炎性细胞因子又会激活更多的白细胞。[3][4][5]
症状和体征
症状包括发烧、疲劳、食欲不振、肌肉和关节疼痛、恶心、呕吐、腹泻、皮疹、呼吸急促、心动过速、低血压、癫痫发作、头痛、精神错乱、谵妄、幻觉、震颤和失去协调。[3]
参考资料
- ^ Cytokine release syndrome. Journal for Immunotherapy of Cancer. June 2018, 6 (1): 56. PMC 6003181
. PMID 29907163. doi:10.1186/s40425-018-0343-9.
- ^ Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era. Arthritis & Rheumatology. June 2017, 69 (6): 1135–1143. PMID 28217930. doi:10.1002/art.40071.
- ^ 3.0 3.1 Current concepts in the diagnosis and management of cytokine release syndrome. Blood. July 2014, 124 (2): 188–95. PMC 4093680 . PMID 24876563. doi:10.1182/blood-2014-05-552729.
- ^ New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management. Critical Care. April 2017, 21 (1): 89. PMC 5391608 . PMID 28407743. doi:10.1186/s13054-017-1678-1.
- ^ Infusion reactions: diagnosis, assessment, and management. Clinical Journal of Oncology Nursing. April 2010, 14 (2): E10–21. PMID 20350882. doi:10.1188/10.CJON.E10-E21.
本文采用了美国卫生与公众服务部文件中的公共领域材料: "Common Terminology Criteria for Adverse Events (CTCAE) Version v4.03"
