8,9-脱氢雌酮
临床资料 | |
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其他名称 | Δ8-Estrone; Estra-1,3,5(10),8-tetraen-3-ol-17-one |
给药途径 | By mouth |
药物类别 | Estrogen |
识别信息 | |
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CAS号 | 474-87-3 |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C18H20O2 |
摩尔质量 | 268.36 g·mol−1 |
3D模型(JSmol) | |
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8,9-脱氢雌酮(英语:8,9-Dehydroestrone,Δ8-estrone)也称为异马烯雌酮(英语:isoequilin)是一种存在于马中的天然雌激素,半系统名:雌甾-1,3,5(10),8-四烯-3-醇-17-酮,estra-1,3,5(10),8-tetraen-3-ol-17-one[1]。8,9-脱氢雌酮的3-硫酸酯是结合型雌激素(普立马)的成分之一,约占3.5%[2]。8,9-脱氢雌酮在体内可转化成8,9-脱氢雌二醇,过程类似于雌酮转化成雌二醇[3][4]。
参考文献
- ^ Baracat E, Haidar M, Lopez FJ, Pickar J, Dey M, Negro-Vilar A. Estrogen activity and novel tissue selectivity of delta8,9-dehydroestrone sulfate in postmenopausal women. J. Clin. Endocrinol. Metab. June 1999, 84 (6): 2020–7. PMID 10372704. doi:10.1210/jcem.84.6.5800 .
- ^ Marc A. Fritz; Leon Speroff. Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. 28 March 2012: 751– [2022-02-06]. ISBN 978-1-4511-4847-3. (原始内容存档于2021-05-03).
- ^ Bhavnani BR. Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism. Proc. Soc. Exp. Biol. Med. January 1998, 217 (1): 6–16. PMID 9421201. S2CID 45177839. doi:10.3181/00379727-217-44199.
- ^ Bhavnani BR, Cecutti A, Gerulath A. Pharmacokinetics and pharmacodynamics of a novel estrogen delta8-estrone in postmenopausal women and men. J. Steroid Biochem. Mol. Biol. October 1998, 67 (2): 119–31. PMID 9877212. S2CID 54352249. doi:10.1016/s0960-0760(98)00082-x.