CD33

CD33
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	5IHB、5J06、5J0B、6D48、6D49、6D4A、6TL8、7AW6
识别号
别名	CD33；, CD33 molecule, SIGLEC-3, SIGLEC3, p67
外部ID	OMIM：159590 MGI：99440 HomoloGene：88651 GeneCards：CD33
相关疾病
	阿茲海默症
为以下药物的标靶
	Tenomodulin
基因位置（人类）
染色体	19号染色体
终止	51,243,860 bp
基因位置（小鼠）
染色体	小鼠7号染色体
终止	43,193,852 bp
基因本体
分子功能	• 血浆蛋白结合; • carbohydrate binding; • signaling receptor activity; • protein phosphatase binding; • sialic acid binding;
细胞组分	• integral component of membrane; • integral component of plasma membrane; • 膜; • external side of plasma membrane; • 细胞核; • 细胞膜; • specific granule membrane; • tertiary granule membrane; • 过氧化物酶体; • 高尔基体;
生物学过程	• cell-cell signaling; • 细胞粘附; • 信号转导; • negative regulation of cell population proliferation; • regulation of immune response; • neutrophil degranulation; • immune response-inhibiting signal transduction; • positive regulation of protein secretion; • 白细胞介素-1β产生的负调控; • negative regulation of interleukin-8 production; • 肿瘤坏死因子产生的负调控; • negative regulation of calcium ion transport; • cell-cell adhesion; • positive regulation of protein tyrosine phosphatase activity; • negative regulation of monocyte activation;
	Sources:Amigo / QuickGO
直系同源
	945
	12489
	ENSG00000105383
	ENSMUSG00000004609
	P20138
	Q63994
	NM_001082618; NM_001177608; NM_001772
	NM_001111058; NM_021293
	NP_001076087; NP_001171079; NP_001763
	NP_001104528; NP_067268
	维基数据
查看/编辑人类	查看/编辑小鼠

CD33或称为Siglec-3（唾液酸结合Ig-样凝集素3，SIGLEC3，SIGLEC-3，gp67，p67）是一个粒细胞系的细胞表面表达的跨膜受体^[7]。它通常被认为是髓源性细胞所特有的，但它也可以在一些淋巴细胞上表达。^[8]

它能与唾液酸结合，因此属于凝集素中的SIGLEC家族。

参考文献

^ 與CD33相關的疾病；在維基數據上查看/編輯參考.
^ 對CD33起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000105383 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000004609 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells. Blood. Feb 2005, 105 (3): 1256–64 [2018-07-15]. PMID 15388576. doi:10.1182/blood-2004-06-2416. （原始内容存档于2019-09-24）.
^ A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. Journal of Leukocyte Biology. Jan 2006, 79 (1): 46–58. PMID 16380601. doi:10.1189/jlb.0205096. ^{[永久失效链接]}

外部链接

Human CD33 genome location and CD33 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[1] 與CD33相關的疾病；在維基數據上查看/編輯參考.

[2] 對CD33起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000105383 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000004609 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15388576-7] Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells. Blood. Feb 2005, 105 (3): 1256–64 [2018-07-15]. PMID 15388576. doi:10.1182/blood-2004-06-2416. （原始内容存档于2019-09-24）.

[pmid16380601-8] A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. Journal of Leukocyte Biology. Jan 2006, 79 (1): 46–58. PMID 16380601. doi:10.1189/jlb.0205096. ^{[永久失效链接]}

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