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L1210细胞

维基百科,自由的百科全书

L1210细胞系(Leukemia 1210)是来源于8个月大的雌性DBA/2近交系小鼠腹水的细胞系,为白血病淋巴细胞[1]。相比B淋巴细胞,L1210在形态上更接近淋巴母细胞英语lymphoblast,可在无胸腺裸鼠注入后7至10天发展成肿瘤[2]。尾静脉注射、腹腔注射或皮下接种L1210细胞可制备白血病小鼠模型[3][4]。有研究指出可以通过睾丸接种L1210细胞,制备小鼠白血病细胞睾丸浸润模型[5]

参考文献

  1. ^ Moore GE, Sandberg AA, Ulrich K. Suspension cell culture and in vivo and in vitro chromosome constitution of mouse leukemia L1210. J. Natl. Cancer Inst. 1960, 36 (3): 405–421. PMID 18630317. doi:10.1093/jnci/36.3.405. 
  2. ^ L1210. [15 July 2018]. (原始内容存档于2019-10-06). 
  3. ^ Kozar, K; Kamiński, R; Switaj, T; Ołdak, T; Machaj, E; Wysocki, PJ; Mackiewicz, A; Lasek, W; Jakóbisiak, M; Gołab, J. Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice.. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003-08-01, 9 (8): 3124–33 [2019-11-23]. PMID 12912964. 
  4. ^ Canti, G; Franco, P; Marelli, O; Ricci, L; Nicolin, A. Hematoporphyrin derivative rescue from toxicity caused by chemotherapy or radiation in a murine leukemia model (L1210).. Cancer research. 1984-04, 44 (4): 1551–6 [2019-11-23]. PMID 6231100. 
  5. ^ Pouillart, P; Huong, TH; Lhéritier, J. [L 1210 leukemia, an experimental model for the potentiation of drugs used for acute leukemias].. Bulletin du cancer. NaN, 61 (4): 509–26 [2019-11-23]. PMID 4458834. 

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