用户:Shangkuanlc/沙盒/利多卡因
临床资料 | |
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读音 | Lidocaine /ˈlaɪdəˌkeɪn/[1][2] Lignocaine /ˈlɪɡnəˌkeɪn/ |
商品名 | Xylocaine |
其他名称 | N-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide |
AHFS/Drugs.com | Local Monograph Injectable Monograph |
怀孕分级 |
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给药途径 | 静脉注射, subcutaneous, 外用药物, 口服给药 |
ATC码 | |
法律规范状态 | |
法律规范 |
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药物动力学数据 | |
生物利用度 | 35% (oral) 3% (topical) |
药物代谢 | 肝脏,[3] 90% CYP1A2-mediated |
药效起始时间 | within 1.5 min (IV)[3] |
生物半衰期 | 1.5–2 hours |
作用时间 | 10 to 20 min(IV)[3], 2 to 3 hrs (injection)[4] |
排泄途径 | 肾[3] |
识别信息 | |
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CAS号 | 137-58-6( 73-78-9 (hydrochloride)) |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
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ChEMBL | |
化学信息 | |
化学式 | C14H22N2O |
摩尔质量 | 234.34 g/mol |
3D模型(JSmol) | |
熔点 | 68 °C(154 °F) |
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Lidocaine, also known as xylocaine and lignocaine, is a medication used to 局部麻醉药 and to treat ventricular tachycardia.[4][3] It can be used for nerve blocks. Lidocaine mixed with a small amount 肾上腺素 is available to allow larger doses to be used as freezing and to make it last longer. As injectable freezing it typically begins working within four minutes and lasts for two to three hours. Lidocaine may also be applied directly to the skin for freezing.[4]
Common side effects with intravenous use include sleepiness, muscle twitching, confusion, changes in vision, numbness, tingling, and vomiting. It can cause 低血压 and an irregular heart rate.[3] There are concerns that injecting it into a joint can cause problems with the 软骨.[4] It appears to be generally safe for use in 妊娠.[3] A lower dose may be required in those with liver problems.[3] It is generally safe to use in those allergic to tetracaine or 苯佐卡因.[4] Lidocaine is an 抗心律失常药 of the class Ib type.[3]
Lidocaine was discovered in 1946 and went on sale in 1948.[5] It is on the 世界卫生组织基本药物标准清单, the most important medications needed in a basic healthcare system.[6] It is available as a generic medication and is not very expensive.[4][7] A vial of medication wholesale is about 0.50 to 1.00 USD.[8]
References
- ^ Lidocaine. Merriam-Webster Dictionary.
- ^ Lidocaine. Dictionary.com Unabridged. Random House.
- ^ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Lidocaine Hydrochloride (Antiarrhythmic). The American Society of Health-System Pharmacists. [Aug 26, 2015].
- ^ 4.0 4.1 4.2 4.3 4.4 4.5 Lidocaine Hydrochloride (Local). The American Society of Health-System Pharmacists. [Aug 26, 2015].
- ^ Pharmaceutical innovation : revolutionizing human health. Philadelphia: Chemical Heritage Press. 1999: 211. ISBN 9780941901215. Authors list列表中的
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(帮助) - ^ WHO Model List of Essential Medicines (PDF). World Health Organization. October 2013 [22 April 2014].
- ^ Hamilton, Richart. Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. 2015: 22. ISBN 9781284057560.
- ^ Lidocaine HCL. International Drug Price Indicator Guide. [27 August 2015].