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伏妥珠单抗

维基百科,自由的百科全书
伏妥珠单抗
单克隆抗体
种类双单链可变区片段英语Single-chain variable fragment
目标CD3英语CD3 (immunology)CD123英语interleukin-3 receptor
临床资料
其他名称MGD006
ATC码
  • 未分配
识别信息
CAS号1664355-28-5
ChemSpider
  • none
UNII
KEGG
化学信息
化学式C2618H4040N704O813S16
摩尔质量58,898.19 g·mol−1

伏妥珠单抗INN:flotetuzumab[1];开发代号:MGD006)是一种双特异性抗体[2]设计用于治疗急性骨髓性白血病[3][4]该药物由MacroGenics公司开发。[5]

参考资料

  1. ^ World Health Organization. International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 118 (PDF). WHO Drug Information. 2017, 31 (4) [2024-03-12]. (原始内容存档 (PDF)于2020-08-15). 
  2. ^ Guy DG, Uy GL. Bispecific Antibodies for the Treatment of Acute Myeloid Leukemia. Curr Hematol Malig Rep. October 2018, 13 (6): 417–425. PMC 6295344可免费查阅. PMID 30280288. doi:10.1007/s11899-018-0472-8. 
  3. ^ Campagne O, Delmas A, Fouliard S, Chenel M, Chichili GR, Li H, Alderson R, Scherrmann JM, Mager DE. Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity. Clin. Cancer Res. June 2018, 24 (11): 2631–2641. PMID 29463552. doi:10.1158/1078-0432.CCR-17-2265可免费查阅. .
  4. ^ Assi R, Kantarjian H, Ravandi F, Daver N. Immune therapies in acute myeloid leukemia: a focus on monoclonal antibodies and immune checkpoint inhibitors. Curr. Opin. Hematol. March 2018, 25 (2): 136–145. PMID 29206680. S2CID 23901088. doi:10.1097/MOH.0000000000000401. 
  5. ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Flotetuzumab页面存档备份,存于互联网档案馆), American Medical Association.