目前并无任何药物治疗和手术能根治克隆氏症。治疗选项(英语:Management of Crohn's disease)的目的在于改善症状,使病情缓解以及预防复发(英语:Relapse)。新诊断为克隆氏症的病人通常会接受短暂的类固醇治疗,使病情有显著的改善,之后并合并灭杀除癌锭或硫嘌呤等药物防止复发。对于有烟瘾的病患来说,在治疗过程中最重要的一部分就是戒烟。患有克隆氏症的病患中,每五位就有一位需要每年定期回医院覆诊,其中约有一半的病患在发病后十年左右需要接受手术治疗。虽然手术并非必要的治疗方式,但适用于脓疡、某些情况下的肠阻塞以及癌症。同时也建议患者在发病的八年后,需要隔几年接受大肠镜,以检查是否有罹患大肠癌[4]。
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