MCR-1

MCR-1是第一种通过mcr-1基因对粘杆菌素（一种多粘菌素和最后一线用药）产生质粒介导（plasmid-mediated）抗生素抗药性的遗传机制^[1]^[2]。此机制最早于2015年11月时在中国猪只中带有的大肠杆菌SHP45型发现，之后并由马来西亚、英国^[3]、中国^[1]、欧洲^[4]和美国^[5]等不同研究单位在人类检体中发现。本机制也是首个可在细菌间以基因水平转移传播的抗多粘菌素机制。

参见

新德里金属-β-内酰胺酶1

参考资料

^ ^1.0 ^1.1 Liu, YY; Wang, Y; Walsh, TR; Yi, LX; Zhang, R; Spencer, J; Doi, Y; Tian, G; Dong, B; Huang, X; Yu, LF; Gu, D; Ren, H; Chen, X; Lv, L; He, D; Zhou, H; Liang, Z; Liu, JH; Shen, J. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.. The Lancet. Infectious diseases. 2015-11-18 [2016-05-27]. PMID 26603172. doi:10.1016/S1473-3099(15)00424-7. （原始内容存档于2018-09-08）（英语）.
^ Reardon, Sara. Spread of antibiotic-resistance gene does not spell bacterial apocalypse — yet. Nature. 2015-12-21 [2016-05-27]. doi:10.1038/nature.2015.19037. （原始内容存档于2020-08-03）（英语）.
^ More MCR-1 findings lead to calls to ban ag use of colistin. 明尼苏达大学传染病研究及政策中心（Center for Infectious Disease Research and Policy）. 2015-12-18 [2015-12-22]. （原始内容存档于2020-02-16）（英语）.
^ McKenna, Maryn. Apocalypse Pig Redux: Last-Resort Resistance in Europe. 国家地理学会. 2015-12-03 [2016-05-27]. （原始内容存档于2016-05-28）（英语）.
^ The U.S. Military HIV Research Program (MHRP). First discovery in United States of colistin resistance in a human E. coli infection. www.sciencedaily.com. 2016-05-26 [2016-05-27]. （原始内容存档于2016-05-27）（英语）.

这是一篇遗传学小作品。您可以通过编辑或修订扩充其内容。

[Lancet-1] 1.0 ^1.1 Liu, YY; Wang, Y; Walsh, TR; Yi, LX; Zhang, R; Spencer, J; Doi, Y; Tian, G; Dong, B; Huang, X; Yu, LF; Gu, D; Ren, H; Chen, X; Lv, L; He, D; Zhou, H; Liang, Z; Liu, JH; Shen, J. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.. The Lancet. Infectious diseases. 2015-11-18 [2016-05-27]. PMID 26603172. doi:10.1016/S1473-3099(15)00424-7. （原始内容存档于2018-09-08）（英语）.

[2] Reardon, Sara. Spread of antibiotic-resistance gene does not spell bacterial apocalypse — yet. Nature. 2015-12-21 [2016-05-27]. doi:10.1038/nature.2015.19037. （原始内容存档于2020-08-03）（英语）.

[3] More MCR-1 findings lead to calls to ban ag use of colistin. 明尼苏达大学传染病研究及政策中心（Center for Infectious Disease Research and Policy）. 2015-12-18 [2015-12-22]. （原始内容存档于2020-02-16）（英语）.

[4] McKenna, Maryn. Apocalypse Pig Redux: Last-Resort Resistance in Europe. 国家地理学会. 2015-12-03 [2016-05-27]. （原始内容存档于2016-05-28）（英语）.

[5] The U.S. Military HIV Research Program (MHRP). First discovery in United States of colistin resistance in a human E. coli infection. www.sciencedaily.com. 2016-05-26 [2016-05-27]. （原始内容存档于2016-05-27）（英语）.

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