顆粒溶素 （英語：Granulysin ，又譯為「顆粒溶解素」）是一種由細胞毒性T細胞 （CD8陽性 T細胞）在接觸被感染的細胞時釋放的物質。其功能為通過靶細胞的膜上形成的小孔，從而誘導靶細胞凋亡 ，另外也與抗微生物相關[1]
顆粒溶素是一種能產生細胞溶解 和發炎反應 的分子，最早通過抑制消減雜交 尋找在人細胞毒性T細胞活化3–5天時表現的基因發現。顆粒溶素會與具有穿孔能力的穿孔素 和顆粒酶 形成溶細胞顆粒。顆粒溶素具有廣譜的抗微生物 功能，能殺傷結核桿菌 、瘧原蟲 等，甚至能殺傷一些腫瘤。一系列源自顆粒溶素的胺基酸序列的多肽 能作為潛在的抗細菌藥 。
顆粒溶素最近被認為與史蒂芬斯－強森症候群 的發生發展有關。
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^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000115523 - Ensembl , May 2017^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.
. PMID 18310138. doi:10.1093/jac/dkn058.