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2-(3,3-二苯基丙基)咪唑-5-乙胺

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2-(3,3-二苯基丙基)咪唑-5-乙胺
別名 二苯丙基組胺(Histaprodifen)
2-(3,3-二苯基丙基)組胺
識別
CAS號 222545-59-7  checkY
SMILES
 
  • N=1C=C(NC1CCC(C=2C=CC=CC2)C=3C=CC=CC3)CCN
性質
化學式 C20H23N3
摩爾質量 305.42 g·mol−1
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

2-(3,3-二苯基丙基)咪唑-5-乙胺一類強效且具有選擇性的組胺H1受體激動劑的母體化合物[1],化學式為C20H23N3,它可以二苯甲烷為原料,經多步反應製得。[2]

它和4-吡啶乙酸鹽酸鹽在吡啶CDI的存在下於THF中反應,可以得到N-[2-(3,3-二苯基丙基)咪唑-5-基乙基]-4-吡啶乙醯胺。[3]

參考文獻

  1. ^ Sigurd Elz, Kai Kramer, Christian Leschke, Walter Schunack. Ring-substituted histaprodifen analogues as partial agonists for histamine H1 receptors: synthesis and structure–activity relationships. European Journal of Medicinal Chemistry, 2000. 35 (1): 41-52. doi:10.1016/S0223-5234(00)00105-7.
  2. ^ Elz S, Kramer K, Pertz HH; et al. Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H1-receptor agonists. J. Med. Chem. 2000, 43 (6): 1071–1084. PMID 10737740. 
  3. ^ Sonja Menghin, Heinz H. Pertz, Kai Kramer, Roland Seifert, Walter Schunack, and Sigurd Elz. Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists. J. Med. Chem. 2003, 46, 25, 5458–5470. doi:10.1021/jm0309147.