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CYP11C1

维基百科,自由的百科全书
cytochrome P450, family 11, subfamily c, polypeptide 1
标识
生物 Danio rerio
符号 CYP11C1
Entrez 791124
RefSeq (mRNA) NM_001080204.1
RefSeq (蛋白质) NP_001073673.1
UniProt A1XRK1
其他数据
EC number 1.14.15.4
染色体 16: 54.46 - 54.48 Mb

Cyp11c1鱼类的一种编码CYP450单加氧酶基因,最早发现于模式动物斑马鱼(学名:Danio rerio),负责催化皮质醇11-酮睾酮(11-KT)的形成[1][2],11-KT是斑马鱼的内源性雄激素

参考文献 

  1. ^ Zhang Q, Ye D, Wang H, Wang Y, Hu W, Sun Y. Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction. Endocrinology. June 2020, 161 (6). PMID 32222764. doi:10.1210/endocr/bqaa048. 
  2. ^ Zheng Q, Xiao H, Shi H, Wang T, Sun L, Tao W, et al. Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone. The Journal of Endocrinology. March 2020, 244 (3): 487–499. PMID 31910154. doi:10.1530/JOE-19-0438.