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醛糖1-脱氢酶 (NAD+)

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醛糖1-脫氫酶 (NAD+)
識別碼
EC編號 1.1.1.121
CAS號 9076-61-3
數據庫
IntEnz IntEnz瀏覽
BRENDA英語BRENDA BRENDA入口
ExPASy英語ExPASy NiceZyme瀏覽
KEGG KEGG入口
MetaCyc英語MetaCyc 代謝路徑
PRIAM英語PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本體 AmiGO / EGO

醛糖1-脫氫酶 (NAD+)(英語:aldose 1-dehydrogenase (NAD+)EC 1.1.1.121頁面存檔備份,存於網際網路檔案館)),是一種以NAD+NADP+受體,其作用於供體CH-OH基團上的氧化還原酶。這種催化以下酶促反應

D-醛糖 + NAD+ D-醛糖酸內酯 + NADH + H+

醛糖1-脫氫酶 (NAD+)也能催化D-葡萄糖、2-脫氧-D-葡萄糖、6-脫氧-D-葡萄糖、D-半乳糖、6-脫氧-D-半乳糖、2-脫氧-L-阿拉伯糖以及D-木糖等發生反應,並會受到1,10-鄰氮二菲2,3-苯並呋喃己二烯雌二醇吲唑吲哚有機分子Ag+Ca2+陽離子的抑制。[1][2][3]

參考文獻

  1. ^ Asada Y, Endo S, Inoue Y, Mamiya H, Hara A, Kunishima N, Matsunaga T. Biochemical and structural characterization of a short-chain dehydrogenase/reductase of Thermus thermophilus HB8: a hyperthermostable aldose-1-dehydrogenase with broad substrate specificity.. Chem. Biol. Interact. 2009, 178 (1-3): 117–126 [2013-07-12]. PMID 18926808. (原始內容存檔於2017-09-07). 
  2. ^ Dahms AS, Anderson RL. D-Fucose metabolism in a pseudomonad. I. Oxidation of D-fucose to D-fucono- -lactone by a D-aldohexose dehydrogenase. J. Biol. Chem. 1972, 247 (7): 2222–2227 [2013-07-12]. PMID 4335867. (原始內容存檔於2016-05-29). 
  3. ^ Nishiya Y, Tamura N, Tamura T. Analysis of bacterial glucose dehydrogenase homologs from thermoacidophilic archaeon Thermoplasma acidophilum: finding and characterization of aldohexose dehydrogenase. Biosci Biotechnol Biochem. 2004, 68 (12): 2451–2456 [2013-07-12]. PMID 4335867. (原始內容存檔於2019-06-14). 
  • Cline AL, Hu AS. The isolation of three sugar dehydrogenases from a psuedomonad原文如此. J. Biol. Chem. 1965, 240 (11): 4488–92. PMID 5845847. 
  • Cline AL, Hu AS. Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad. J. Biol. Chem. 1965, 240 (11): 4493–7. PMID 5845848. 
  • Cline AL, Hu AS. Some physical properties of three sugar dehydrogenases from a pseudomonad. J. Biol. Chem. 1965, 240 (11): 4498–502. PMID 5845849.