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阿利魯單抗

維基百科,自由的百科全書
阿利魯單抗
單克隆抗體
種類?
目標整合素α4β7英語LPAM-1
臨床資料
其他名稱AMG 181
ATC碼
  • 未分配
識別資訊
CAS號1342290-43-0
ChemSpider
  • none
UNII
KEGG
化學資訊
化學式C6362H9806N1686O2014S52
摩爾質量143,803.34 g·mol−1

阿利魯單抗INN:abrilumab;開發代號:AMG 181)是一種抗α4β7英語LPAM-1單克隆抗體[1]設計用於治療炎症性腸病[1]潰瘍性結腸炎[2]克羅恩病[3]

該藥物由安進公司阿斯利康旗下的MedImmune英語MedImmune開發。[4]針對該藥物的開發已於2016年停止。[5]

參考資料

  1. ^ 1.0 1.1 Sandborn, William J.; Cyrille, Marcoli; Hansen, Mark Berner; Feagan, Brian G.; Loftus, Edward V.; Rogler, Gerhard; Vermeire, Severine; Cruz, Martha L.; Yang, Jun; Boedigheimer, Michael J.; Abuqayyas, Lubna. Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis. Gastroenterology. 2019-03, 156 (4). ISSN 1528-0012. PMID 30472236. doi:10.1053/j.gastro.2018.11.035. 
  2. ^ Hibi, Toshifumi; Motoya, Satoshi; Ashida, Toshifumi; Sai, Souken; Sameshima, Yukinori; Nakamura, Shiro; Maemoto, Atsuo; Nii, Masahiro; Sullivan, Barbara A.; Gasser, Robert A.; Suzuki, Yasuo. Efficacy and safety of abrilumab, an α4β7 integrin inhibitor, in Japanese patients with moderate-to-severe ulcerative colitis: a phase II study. Intestinal Research. 2019-07, 17 (3). ISSN 1598-9100. PMC 6667363可免費查閱. PMID 30739435. doi:10.5217/ir.2018.00141. 
  3. ^ Pan, Wei-Jian; Köck, Kathleen; Rees, William A; Sullivan, Barbara A; Evangelista, Christine M; Yen, Mark; Andrews, Jane M; Radford-Smith, Graham L; Prince, Peter J; Reynhardt, Kaz O; Doherty, David R. Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7 monoclonal antibody, for treating inflammatory bowel diseases. British Journal of Clinical Pharmacology. 2014-12, 78 (6). ISSN 0306-5251. PMC 4256621可免費查閱. PMID 24803302. doi:10.1111/bcp.12418. 
  4. ^ Abrilumab - Amgen/AstraZeneca - AdisInsight. adisinsight.springer.com. [2024-05-25]. 
  5. ^ abrilumab | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY. www.guidetopharmacology.org. [2024-05-25].