MYO5A

MYO5A
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	4J5L、4LX1、4LX2、4LLI、4D07
識別號
別名	MYO5A；, GS1, MYH12, MYO5, MYR12, myosin VA
外部ID	OMIM：160777 MGI：105976 HomoloGene：20100 GeneCards：MYO5A
基因位置（人類）
染色體	15號染色體
終止	52,529,132 bp
基因位置（小鼠）
染色體	小鼠9號染色體
終止	75,130,970 bp
RNA表現模式
	查閱更多表現資料
基因本體
分子功能	• calcium ion binding; • 核苷酸結合; • calmodulin binding; • microfilament motor activity; • actin binding; • cytoskeletal motor activity; • ATP結合; • RNA binding; • 無序域特異性結合; • 相同蛋白質結合; • 血漿蛋白結合; • actin filament binding;
細胞組分	• 細胞質; • recycling endosome; • 囊泡; • 細胞質基質; • 晚期內吞體; • 高基氏體; • 膜; • 生長錐; • ruffle; • 黑色素體; • insulin-responsive compartment; • photoreceptor outer segment; • 過氧化體; • secretory granule; • microtubule plus-end; • filopodium tip; • soma; • 早期內吞體; • 內質網; • 微絲; • neuron projection; • 溶體; • actomyosin; • 中間纖維; • 外排體; • myosin complex; • unconventional myosin complex; • smooth endoplasmic reticulum; • postsynapse; • glutamatergic synapse;
生物學過程	• regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; • melanin biosynthetic process; • synapse organization; • insulin secretion; • secretory granule localization; • melanosome localization; • actin filament-based movement; • post-Golgi vesicle-mediated transport; • odontogenesis; • endoplasmic reticulum localization; • melanin metabolic process; • regulation of Golgi organization; • long-chain fatty acid biosynthetic process; • melanosome transport; • cellular response to insulin stimulus; • vesicle transport along actin filament; • protein transport; • developmental pigmentation; • 髓鞘形成; • 色素沉著; • protein localization to plasma membrane; • melanocyte differentiation; • locomotion involved in locomotory behavior; • vesicle-mediated transport; • 視覺; • 胞吐作用; • 化學性突觸傳遞; • hair follicle maturation; • transport; • establishment of endoplasmic reticulum localization to postsynapse; • regulation of postsynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
直系同源
	4644
	17918
	ENSG00000197535
	ENSMUSG00000034593
	Q9Y4I1
	Q99104
	NM_000259; NM_001142495; NM_001382347; NM_001382348; NM_001382349
	NM_010864
	NP_000250; NP_001135967; NP_001369276; NP_001369277; NP_001369278
	NP_034994
	維基資料
檢視/編輯人類	檢視/編輯小鼠

MYO5A是一個位於人類15號染色體上的基因，編碼一種隸屬肌凝蛋白超家族的非典型的肌凝蛋白肌凝蛋白-Va（Myosin-Ia）。肌凝蛋白-Va與細胞內囊泡、胞器，以及蛋白複合體通過微絲纖維運輸有關^[5]^[6]^[7]^[8]^[9]^[10]。

參見

肌凝蛋白

參考資料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197535 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034593 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Velvarska, Hana; Niessing, Dierk. Structural Insights into the Globular Tails of the Human Type V Myosins Myo5a, Myo5b, and Myo5c. PLOS ONE. 2013-12-10, 8 (12): e82065. Bibcode:2013PLoSO...882065V. ISSN 1932-6203. PMC 3858360 . PMID 24339992. doi:10.1371/journal.pone.0082065.
^ Wöllert, Torsten; Patel, Anamika; Lee, Ying-Lung; Provance, D. William; Vought, Valarie E.; Cosgrove, Michael S.; Mercer, John A.; Langford, George M. Myosin5a Tail Associates Directly with Rab3A-containing Compartments in Neurons. The Journal of Biological Chemistry. 2011-04-22, 286 (16): 14352–14361. ISSN 0021-9258. PMC 3077635 . PMID 21349835. doi:10.1074/jbc.M110.187286.
^ Schumacher-Bass, Sarah M.; Vesely, Eileen D.; Zhang, Lian; Ryland, Katherine E.; McEwen, Dyke P.; Chan, Priscilla J.; Frasier, Chad R.; McIntyre, Jeremy C.; Shaw, Robin M.; Martens, Jeffrey R. A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes. Circulation Research. 2014-03-14, 114 (6): 982–992. ISSN 0009-7330. PMC 4213814 . PMID 24508725. doi:10.1161/CIRCRESAHA.114.302711.
^ Engle LJ, Kennett RH. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics. Feb 1994, 19 (3): 407–16. PMID 8188282. doi:10.1006/geno.1994.1088.
^ Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. PMC 44240 . PMID 8022818. doi:10.1073/pnas.91.14.6549.
^ Entrez Gene: MYO5A myosin VA (heavy chain 12, myoxin).

這是一篇與生物化學相關的小作品。您可以透過編輯或修訂擴充其內容。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197535 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034593 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] Velvarska, Hana; Niessing, Dierk. Structural Insights into the Globular Tails of the Human Type V Myosins Myo5a, Myo5b, and Myo5c. PLOS ONE. 2013-12-10, 8 (12): e82065. Bibcode:2013PLoSO...882065V. ISSN 1932-6203. PMC 3858360 . PMID 24339992. doi:10.1371/journal.pone.0082065.

[:1-6] Wöllert, Torsten; Patel, Anamika; Lee, Ying-Lung; Provance, D. William; Vought, Valarie E.; Cosgrove, Michael S.; Mercer, John A.; Langford, George M. Myosin5a Tail Associates Directly with Rab3A-containing Compartments in Neurons. The Journal of Biological Chemistry. 2011-04-22, 286 (16): 14352–14361. ISSN 0021-9258. PMC 3077635 . PMID 21349835. doi:10.1074/jbc.M110.187286.

[:2-7] Schumacher-Bass, Sarah M.; Vesely, Eileen D.; Zhang, Lian; Ryland, Katherine E.; McEwen, Dyke P.; Chan, Priscilla J.; Frasier, Chad R.; McIntyre, Jeremy C.; Shaw, Robin M.; Martens, Jeffrey R. A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes. Circulation Research. 2014-03-14, 114 (6): 982–992. ISSN 0009-7330. PMC 4213814 . PMID 24508725. doi:10.1161/CIRCRESAHA.114.302711.

[pmid8188282-8] Engle LJ, Kennett RH. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics. Feb 1994, 19 (3): 407–16. PMID 8188282. doi:10.1006/geno.1994.1088.

[pmid8022818-9] Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. PMC 44240 . PMID 8022818. doi:10.1073/pnas.91.14.6549.

[entrez-10] Entrez Gene: MYO5A myosin VA (heavy chain 12, myoxin).

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]