FOXP3 識別號 别名 FOXP3 ;, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3外部ID OMIM :300292 MGI :1891436 HomoloGene :8516 GeneCards :FOXP3 相關疾病 IPEX症候群 [ 1] RNA表达 模式查阅更多表达数据 基因本體 分子功能 • sequence-specific DNA binding • NF-kappaB binding • transcription corepressor activity • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • 血浆蛋白结合 • histone deacetylase binding • DNA结合转录因子活性 • NFAT protein binding • histone acetyltransferase binding • 金屬離子結合 • DNA结合 • protein homodimerization activity • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II cis-regulatory region sequence-specific DNA binding 細胞組分 • 细胞核 • 胞內 • 細胞質 • 核质 • 大分子复合体 生物學過程 • negative regulation of cell population proliferation • negative regulation of NF-kappaB transcription factor activity • B cell homeostasis • regulation of isotype switching to IgG isotypes • myeloid cell homeostasis • negative regulation of inflammatory response • positive regulation of interleukin-4 production • regulation of immunoglobulin production • regulation of transcription by RNA polymerase II • regulation of T cell anergy • negative regulation of interleukin-6 production • tolerance induction to self antigen • regulation of transcription, DNA-templated • negative regulation of DNA-binding transcription factor activity • positive regulation of T cell tolerance induction • negative regulation of immune response • negative regulation of interferon-gamma production • tolerance induction • regulatory T cell differentiation • positive regulation of transcription, DNA-templated • negative regulation of interleukin-2 production • positive regulation of histone acetylation • negative regulation of interleukin-5 production • negative regulation of chronic inflammatory response • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of activated T cell proliferation • positive regulation of gene expression • negative regulation of interleukin-4 production • negative regulation of interleukin-10 production • 腫瘤壞死因子產生的負調控 • T cell homeostasis • negative regulation of CREB transcription factor activity • negative regulation of T-helper 17 cell differentiation • T细胞活化 • positive regulation of immature T cell proliferation in thymus • positive regulation of regulatory T cell differentiation • negative regulation of transcription by RNA polymerase II • positive regulation of peripheral T cell tolerance induction • positive regulation of transforming growth factor beta1 production • negative regulation of transcription, DNA-templated • negative regulation of lymphocyte proliferation • negative regulation of histone acetylation • negative regulation of interleukin-17 production • response to virus • negative regulation of histone deacetylation • CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • negative regulation of T cell proliferation • 染色体重建 • cytokine production • negative regulation of T cell cytokine production • negative regulation of isotype switching to IgE isotypes • T cell receptor signaling pathway • positive regulation of T cell anergy • transcription, DNA-templated • T cell mediated immunity • negative regulation of gene expression • anatomical structure morphogenesis • regulation of Wnt signaling pathway • regulation of regulatory T cell differentiation Sources:Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez Ensembl UniProt mRNA序列 蛋白序列 基因位置(UCSC) Chr X: 49.25 – 49.27 Mb Chr X: 7.44 – 7.46 Mb PubMed 查找[ 4] [ 5] 維基數據
FOXP3 (Forkhead box protein P3)基因,即叉头框P3 基因,也称为scurfin 蛋白,位于X染色体 ,属于FOX蛋白 家族,是一种与免疫系统 响应 有关的转录因子 [ 6] 。
参考文献
^ 與FOXP3相關的疾病;在維基數據上查看/編輯參考 .
^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000049768 - Ensembl , May 2017
^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000039521 - Ensembl , May 2017
^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nature Genetics. January 2001, 27 (1): 68–73. PMID 11138001 . S2CID 13389419 . doi:10.1038/83784 .
外部链接
(2.2) 其他的Cys4 结构
(2.3) Cys2 His2
(2.4) Cys6
(2.5)交替composition
(3.2)配对框
(3.6)TEA结构域
transcriptional enhancer factor (
1 、
2 、
3 、
4 )
(4) 具有小凹槽触点的β-支架因子
(4.3) p53样转录因子
(4.11) Runt
(0) 其他转录因子
(0.2) HMGI(Y)
(0.6) Miscellaneous