味觉感受器,类型2,成员60,TAS2R60 是一个人类基因组中TAS2R60 基因编码的蛋白质,是苦味味觉感受器的一员。[ 1] [ 2]
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Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554 . doi:10.1074/jbc.R100054200 .
Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982 . doi:10.1016/S0959-4388(02)00345-8 .
Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932 . doi:10.1073/pnas.242603899 .
Zhang Y; Hoon MA; Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003, 112 (3): 293–301. PMID 12581520 . doi:10.1016/S0092-8674(03)00071-0 .
Shi P, Zhang J, Yang H, Zhang YP. Adaptive diversification of bitter taste receptor genes in Mammalian evolution . Mol. Biol. Evol. 2004, 20 (5): 805–14. PMID 12679530 . doi:10.1093/molbev/msg083 .
Scherer SW; Cheung J; MacDonald JR; et al. Human Chromosome 7: DNA Sequence and Biology . Science. 2003, 300 (5620): 767–72. PMC 2882961 . PMID 12690205 . doi:10.1126/science.1083423 .
Gerhard DS; Wagner L; Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334 . doi:10.1101/gr.2596504 .
Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes . Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549 . doi:10.1093/molbev/msi027 .
Go Y, Satta Y, Takenaka O, Takahata N. Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates . Genetics. 2006, 170 (1): 313–26. PMC 1449719 . PMID 15744053 . doi:10.1534/genetics.104.037523 .