E2F1

維基百科，自由的百科全書
E2F transcription factor 1
PDB rendering based on 2aze.
有效結構
PDB 直系同源檢索：PDBe, RCSB
標識
代號 E2F1; E2F-1; RBAP1; RBBP3; RBP3
擴展標識 遺傳學：189971 鼠基因：101941 同源基因：3828 ChEMBL: 4382 GeneCards: E2F1 Gene
RNA表達模式
更多表達數據
直系同源體
物種 人類 小鼠
Entrez 1869 13555
Ensembl ENSG00000101412 ENSMUSG00000027490
UniProt Q01094 Q61501
mRNA序列 NM_005225 NM_007891
蛋白序列 NP_005216 NP_031917
基因位置 Chr 20:
32.26 – 32.27 Mb		 Chr 2:
154.56 – 154.57 Mb
PubMed查詢 [1] [2]

轉錄因子E2F1是由人類E2F1基因編碼出的蛋白質[1]。

該基因編碼出的蛋白質是E2F轉錄因子家族中的成員。E2F家族在控制細胞周期及抑癌基因功能上起到重要作用，也是小DNA致癌病毒轉化蛋白的靶點。E2F家族中的多個成員蛋白包含許多進化保守的結構域。這些結構域包括：DNA結合域、與受分化調控的轉錄因子蛋白（DP）之間相互作用的二聚化結構域、富含酸性胺基酸的轉活化結構域以及位於轉活化結構域中的抑癌蛋白關聯結構域。該蛋白與其他兩個成員E2F2及E2F3具有額外的周期蛋白結合結構域。該蛋白以細胞周期依賴性的模式優先與視網膜母細胞瘤蛋白pRB結合。它可以同時介導細胞增殖及p53-依賴/非依賴的細胞凋亡[2]。

轉錄

E2F1的啟動子區有PAX8轉錄因子的結合序列，可促進E2F1的轉錄[3]。

相互作用

E2F1與下列蛋白具有相互作用：NCOA6[4]、視網膜母細胞瘤樣蛋白1[5]、視網膜母細胞瘤蛋白[5][6][7][8][9][10][11]、GTF2H1[12]、SKP2[13] PURA,[14]、NPDC1[15]、Sp2轉錄因子[16]、Sp1轉錄因子[16][17][18]、CUL1[13] ARID3A,[19]、TOPBP1[20][21]、周期蛋白A1[22]、TP53BP1[8]、周期蛋白A2[23]、Sp4轉錄因子[16]、Sp3轉錄因子[16]、抗增殖蛋白[24][25][26][27]、NDN[11][28]、MDM4[29] TFDP1[10][19][30][31]及泛素C[32]。

另見

參考文獻

  1. ^ Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG Jr. Structure and partial genomic sequence of the human E2F1 gene. Gene. December 1996, 173 (2): 163–9. PMID 8964493. doi:10.1016/0378-1119(96)00184-9. 
  2. ^ Entrez Gene: E2F1 E2F transcription factor 1. （原始內容存檔於2019-10-16）. 
  3. ^ Li, C G; Nyman, J E; Braithwaite, A W; Eccles, M R. PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene. 2011, 30 (48): 4824–4834. ISSN 0950-9232. doi:10.1038/onc.2011.190. 
  4. ^ Kong, Hee Jeong; Yu Hyun Jung, Hong SunHwa, Park Min Jung, Choi Young Hyun, An Won Gun, Lee Jae Woon, Cheong JaeHun. Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation. Mol. Cancer Res. (United States). November 2003, 1 (13): 948–58. ISSN 1541-7786. PMID 14638867. 
  5. ^ 5.0 5.1 Dyson, N; Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J. Virol. (UNITED STATES). December 1993, 67 (12): 7641–7. ISSN 0022-538X. PMC 238233 可免費查閱. PMID 8230483. 
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  14. ^ Darbinian, N; Gallia G L, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K. Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1. Oncogene (ENGLAND). November 1999, 18 (46): 6398–402. ISSN 0950-9232. PMID 10597240. doi:10.1038/sj.onc.1203011. 
  15. ^ Sansal, I; Dupont E, Toru D, Evrard C, Rouget P. NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity. Oncogene (ENGLAND). October 2000, 19 (43): 5000–9. ISSN 0950-9232. PMID 11042687. doi:10.1038/sj.onc.1203843. 
  16. ^ 16.0 16.1 16.2 16.3 Rotheneder, H; Geymayer S, Haidweger E. Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter. J. Mol. Biol. (ENGLAND). November 1999, 293 (5): 1005–15. ISSN 0022-2836. PMID 10547281. doi:10.1006/jmbi.1999.3213. 
  17. ^ Lin, S Y; Black A R, Kostic D, Pajovic S, Hoover C N, Azizkhan J C. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1668–75. ISSN 0270-7306. PMC 231153 可免費查閱. PMID 8657142. 
  18. ^ Karlseder, J; Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1659–67. ISSN 0270-7306. PMC 231152 可免費查閱. PMID 8657141. 
  19. ^ 19.0 19.1 Suzuki, M; Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K. A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer. Oncogene (ENGLAND). August 1998, 17 (7): 853–65. ISSN 0950-9232. PMID 9780002. doi:10.1038/sj.onc.1202163. 
  20. ^ Liu, Kang; Lin Fang-Tsyr, Ruppert J Michael, Lin Weei-Chin. Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol. Cell. Biol. (United States). May 2003, 23 (9): 3287–304. ISSN 0270-7306. PMC 153207 可免費查閱. PMID 12697828. doi:10.1128/MCB.23.9.3287-3304.2003. 
  21. ^ Yu, Xiaochun; Chini Claudia Christiano Silva, He Miao, Mer Georges, Chen Junjie. The BRCT domain is a phospho-protein binding domain. Science (United States). October 2003, 302 (5645): 639–42. PMID 14576433. doi:10.1126/science.1088753. 
  22. ^ Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 可免費查閱. PMID 10022926. 
  23. ^ Xu, M; Sheppard K A, Peng C Y, Yee A S, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol. (UNITED STATES). December 1994, 14 (12): 8420–31. ISSN 0270-7306. PMC 359381 可免費查閱. PMID 7969176. 
  24. ^ Joshi, Bharat; Ko Danette, Ordonez-Ercan Dalia, Chellappan Srikumar P. A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis. Biochem. Biophys. Res. Commun. (United States). December 2003, 312 (2): 459–66. ISSN 0006-291X. PMID 14637159. doi:10.1016/j.bbrc.2003.10.148. 
  25. ^ Fusaro, Gina; Dasgupta Piyali, Rastogi Shipra, Joshi Bharat, Chellappan Srikumar. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J. Biol. Chem. (United States). November 2003, 278 (48): 47853–61. ISSN 0021-9258. PMID 14500729. doi:10.1074/jbc.M305171200. 
  26. ^ Wang, Sheng; Zhang Baohua, Faller Douglas V. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J. (England). June 2002, 21 (12): 3019–28. ISSN 0261-4189. PMC 126057 可免費查閱. PMID 12065415. doi:10.1093/emboj/cdf302. 
  27. ^ Wang, S; Nath N, Fusaro G, Chellappan S. Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals. Mol. Cell. Biol. (UNITED STATES). November 1999, 19 (11): 7447–60. ISSN 0270-7306. PMC 84738 可免費查閱. PMID 10523633. 
  28. ^ Kuwako, Ken-ichiro; Taniura Hideo, Yoshikawa Kazuaki. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J. Biol. Chem. (United States). January 2004, 279 (3): 1703–12. ISSN 0021-9258. PMID 14593116. doi:10.1074/jbc.M308454200. 
  29. ^ Strachan, Gordon D; Jordan-Sciutto Kelly L, Rallapalli Ravikumar, Tuan Rocky S, Hall David J. The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. J. Cell. Biochem. (United States). February 2003, 88 (3): 557–68. ISSN 0730-2312. PMID 12532331. doi:10.1002/jcb.10318. 
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  32. ^ Zhou, Fangfang; Zhang Long, Wang Aijun, Song Bo, Gong Kai, Zhang Lihai, Hu Min, Zhang Xiufang, Zhao Nanming, Gong Yandao. The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J. Biol. Chem. (United States). May 2008, 283 (21): 14506–15. ISSN 0021-9258. PMID 18367454. doi:10.1074/jbc.M706136200. 

PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells.[永久失效連結]

深入閱讀

  • Dupont E, Sansal I, Toru D; et al. [Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]. C. R. Seances Soc. Biol. Fil. 1997, 191 (1): 95–104. PMID 9181131. 
  • Stevens C, La Thangue NB. The emerging role of E2F-1 in the DNA damage response and checkpoint control.. DNA Repair (Amst.). 2005, 3 (8-9): 1071–9. PMID 15279795. doi:10.1016/j.dnarep.2004.03.034. 
  • Zhang Z, Wang H, Li M; et al. Novel MDM2 p53-independent functions identified through RNA silencing technologies.. Ann. N. Y. Acad. Sci. 2006, 1058 (1): 205–14. PMID 16394138. doi:10.1196/annals.1359.030. 
  • Schild C, Wirth M, Reichert M, Schmid RM, Saur D, Schneider G. PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells. Mol. Carcinog. July 2009, 48 (12): 1149–58. PMID 19603422. doi:10.1002/mc.20569. 

外部連結

E2F1引用了美國國家醫學圖書館提供的資料，這些資料屬於公共領域。

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